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Figure 1 | BMC Neurology

Figure 1

From: Diseased muscles that lack dystrophin or laminin-α2 have altered compositions and proliferation of mononuclear cell populations

Figure 1

The composition of mononucleate cells was altered in Lama2 -/- and mdx diseased muscles compared to healthy muscles. Mononucleate cells were prepared from muscles of Lama2 -/- (3 week old), mdx (7.5 weeks old), and age- and strain-matched control mice and analyzed by FACS for expression of Sca-1 and CD45. A. Scatter-plots of a representative FACS study of the different cell subsets defined by Sca-1 and CD45 expression patterns in normal C57BL/10ScSn (left) and mdx (right) muscles. B. Scatter-plots of a representative FACS study of the different cell subsets in normal C57BL/6J (right) and Lama2 -/- (left) muscles. Significant differences were observed in the distribution of cells between the wild type and disease conditions (see Fig. 2 and Table 1 for quantitative and statistical analyses). As also noted in the text, mdx muscles contained several-fold more mononucleate cells per gram of tissue than Lama2 -/- muscles.

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BMC Neurology

ISSN: 1471-2377

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