Skip to main content

Table 1 Patterns of expression of Sca-1 and CD45 by mononucleate cells derived from healthy and diseased skeletal muscles.

From: Diseased muscles that lack dystrophin or laminin-α2 have altered compositions and proliferation of mononuclear cell populations

   Percentage of cells with indicated expression pattern1
Age Genotype Sca-1+/CD45- Sca-1+/CD45+ Sca-1-/CD45+ Sca-1-/CD45-
3 weeks C57BL/6 5.9 ± 3.5 1.0 ± 0.4 4.7 ± 1.7 88.0 ± 5.3
  Lama2 -/- 5.6 ± 1.8 3.3 ± 0.4 38.9 ± 15.9 52.2 ± 15.6
   P > 0.1 P < 0.03* P < 0.01* P < 0.01*
4 weeks C57BL/10 12.0 ± 6.7 1.2 ± 0.2 8.3 ± 2.2 78.6 ± 4.3
  mdx 21.0 ± 7.4 6.4 ± 2.4 55.8 ± 11.3 16.7 ± 6.2
   P > 0.1 P = 0.09 P < 0.03* P < 0.01*
7.5 weeks C57BL/10 2.5 ± 0.6 0.2 ± 0.1 5.1 ± 0.2 92.0 ± 0.6
  mdx 1.8 ± 0.5 0.8 ± 0.3 28.9 ± 3.6 68.5 ± 4.1
   P > 0.1 P = 0.03* P < 0.01* P < 0.01*
  1. 1Data are presented as ave. ± SD with n = 3 for all except 4 week old values where n = 2.
  2. Unpaired, two-tailed t-tests (see Methods) were used to compare values from each pair of healthy and diseased muscles that were of the same age and expression pattern. P values are shown below the pair of tested values. P ≤ 0.05 was considered significant and indicated by an asterisk.