Figure 5
From: Analysis of IFT74as a candidate gene for chromosome 9p-linked ALS-FTD
Sequence variants in IFT74 are linked to Chromosome 9p ALS-FTD. (A) Schematic of IFT74's structure. (B) Sequence variants I55L, G58D and Q342X are shown relative to affected protein domains and are indicated by black arrowheads. Human IFT74 protein aligned with other orthologs from chimpanzee (XP_520518.1), dog (XP_531964.1), mouse (AAH23760.1) and rat (NP_001007002.1). Amino acid number is based on the human protein. (C) chromatograms showing wild type (top), forward mutant (middle) and reverse mutant (bottom) sequences of I55L (left), G58D (middle) and Q342X (right).