TRPV3 and TRPV1 immunoreactivity in diabetic skin. TRPV3-immunoreactive basal keratinocytes in control (A) and diabetic (B) skin. TRPV1-immunoreactive dermal and epidermal (arrows in C) fibers in control (C) and diabetic (D) skin. TRPV4 – immunoreactivity in keratinocytes (E) and nerve marker (peripherin PPN) in control skin (F). Scale bar = 50 μm A, B, D, E ; 25 μm C, F.