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Table 1 Overview of sensory small fibre tests and correlations. All data presented from the leg.

From: Use of the novel contact heat evoked potential stimulator (CHEPS) for the assessment of small fibre neuropathy: correlations with skin flare responses and intra-epidermal nerve fibre counts

  

Patients

Controls

Correlations

Contact heat evoked potentials

Latency (ms)

509 ± 0.015

525 ± 0.017

-

 

Amplitude (μV)

3.63 ± 0.85

11.7 ± 1.95

• PGP 9.5 and TRPV1 IEF

• Flare area

Skin biopsy (IEF/mm)

PGP 9.5

3.76 ± 0.48

6.52 ± 1.43

• Flare area

• Evoked potential amplitude

 

TRPV1

3.45 ± 0.52

5.7 ± 1.4

• Evoked potential amplitude

Skin flare

Area (cm2)

12.03 ± 0.90

18.14 ± 2.28

• PGP 9.5 IEF

• Evoked potential amplitude

QST (°C change)

Warm

8.2 ± 0.8

6.3 ± 0.3

-

 

Heat

13.97 ± 0.6

10.1 ± 0.2

-

 

Cool

3.6 ± 0.6

2.1 ± 0.1

-