Figure 3

a-b: Segregation pattern of genetic variation in family F. Parents of the two affected are 1^st cousins. One affected (II.2) is married to his 1^st cousin, whereas the other affected (II.4), is married to his 3^rd cousin. a Segregation of haplotype and parkin exon 4 deletion. Both patients were homozygous for a haplotype of four parkin microsatellite markers, and an exon 4 deletion was found to segregate with disease in the family. Gray area denotes haplotype containing exon 4 deletion. b Segregation of substitutions observed in PINK1. Both affected are compound heterozygous for the substitutions generally evaluated as common polymorphisms. One of the children, III.2, had a microsatellite mutation or a rarer double recombination (arrow). The fragment lengths of microsatellite markers D6S1599, D6S305, D6S411 and D6S1550 are listed beneath each individual.