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Table 4 Effect of the APOE ε4 allele on age at onset in LOAD and EOAD

From: APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

  Number of APOE ε4-alleles
  0   1   2  
EOAD. Age at onset ± SD, n 57.3 ± 4.0 14 57.3 ± 4.7 16 58.7 ± 2.6 10
LOAD. Age at onset ± SD, n 78.4 ± 5.8 121 75.3 ± 5.8a 168 72.9 ± 5.0b 47
  1. SD = Standard deviation
  2. n = number of patients
  3. EOAD: Early onset Alzheimer's disease (onset < 65 years), no significant difference in onset between carriers of none, one and two APOE ε4 alleles.
  4. LOAD: Late onset Alzheimer's disease (onset ≥ 65 years)
  5. a: The difference between onset in LOAD (Late Onset AD) in carriers of none and one APOE ε4 allele was significant; p = 0.005.
  6. b: The difference between onset in LOAD in carriers of one and two APOE ε4 alleles was significant; p = 0.002.