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Table 3 Mean MSIS-29 scores and change scores for patients and proxies at baseline and after treatment according to the transition ratings

From: The size of the treatment effect: do patients and proxies agree?

 

Not improveda (n = 25)

Improvedb (n = 17)

MSIS-29

Patients

Proxy respondents

Patients

Proxy respondents

Physical scale baseline

51.3 ± 16.5

51.0 ± 15.0

45.2 ± 20.9

44.2 ± 21.4

Physical scale after treatment

51.1 ± 16.8

55.0 ± 15.0

28.8 ± 17.7

29.5 ± 19.0

Change on MSIS-29 physical scalec

-0.2 ± 12.8

4.0 ± 13.5

-16.4 ± 16.4

-14.7 ± 13.3

Responsiveness ratio

1.29

1.09

Difference between change scoresd:

-4.2 ± 14.7 (p = 0.948)

-1.8 ± 15.1 (p = 0.733)

95% CI of the difference

(-11.7 – 3.3)

(-12.2 – 8.6)

ICC

0.36

0.50

Psychological scale baseline

30.7 ± 19.1

33.2 ± 18.3

32.5 ± 20.9

36.9 ± 23.5

Psychological scale after treatment

30.7 ± 17.7

40.1 ± 22.3

23.4 ± 17.6

26.6 ± 16.8

Change on MSIS-29 psychological scalec

0.0 ± 14.3

6.9 ± 19.9

-9.1 ± 15.3

-10.3 ± 16.3

Responsiveness ratio

0.64

0.52

Difference between change scoresd:

-6.9 ± 18.3 (p = 0.544)

1.1 ± 23.1 (p = 0.834)

95% CI of the difference

(-16.7 – 3.0)

(-8.9 – 12.2)

ICC

0.42

0.0

  1. a combines the transition ratings 'not at all' – 'a little'
  2. b combines the transition ratings 'moderately' – 'quite a lot' – 'completely'
  3. c mean MSIS-29 scores after treatment minus mean MSIS-29 scores at baseline (negative values indicate improvement)
  4. d patient mean change score minus proxy mean change score
  5. CI = Confidence Interval
  6. ICC = Intraclass correlation coefficient