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Table 1 Analysis of six randomized controlled trials reporting measures of spasticity after THC-CBD treatment

From: Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

  Killestein 2002 [15] Wade 2003 [17] Zajicek 2003 [16] Wade 2004 [19] Vaney 2004 [18] Collin 2007 [20]
Design Crossover Crossover Parallel Parallel Crossover Parallel
Jaded score 4 4 5 5 5 4
Study objective Small study to compare effects of THC and THC-CBD Pilot study to explore benefits for neurogenic symptoms Large study to compare effects of THC and THC-CBD Benefits over a range of symptoms Effects on spasm frequency Effects on spasticity
Sample size 16 14 395 (198 placebo) 154 (77 placebo) 57 184 (64 placebo)
Duration 4 weeks 4 weeks 15 weeks 6 weeks 2 weeks 6 weeks
Intervention THC-CBD <10 mg daily THC-CBD 2.5-120 mg daily THC-CBD <25 mg daily THC-CBD <120 mg daily THC-CBD <30 mg daily THC-CBD >25 mg daily
Ashworth score       
Mean change App. -.3 No change 1.24 -0.37 -2.2 -0.64
P-value Not significant >0.05 0.29 0.22 0.002 0.218
VAS spasticity    Not reported   Not reported Not reported
Mean change No change Reduced 14.9 points   Reduced 31.2 points   
P-value Not significant <0.05   0.001   
Walk time Not reported Not reported    Not reported Not reported
Mean change    Reduced 4% Reduced 2.78 (s)   
P-value    Not reported 0.07   
RMI Not reported    Not reported   Not reported
Mean change   Improved 0.2 Improved 0.4   Improved 0.5  
P-value   >0.05 0.21   0.005  
Self-reported rating       
Measure Global impression VAS Numerical symptom scale Category rating scale Diary entry VAS scale Spasm frequency scale Numerical rating scale
Mean change Worsened Frequency reduced 1.9; severity reduced 2.1 52% treated reported improvement Frequency score reduced 21.41; severity reduced 21.67 Reduced 0.4 Reduced 1.18
P-value 0.02 <0.05 0.01 0.009 <0.001 0.048
Adverse events 41 reported, none serious 16 reported 12 serious reported 4% withdrawn No serious reported 4.8% withdrawn
  1. RMI, Rivermead Mobility Index; VAS, Visual Analogue Scale.