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Table 2 Laboratory features between NMOSD without and with autoimmune diseases, and between NMOSD with non-organ-specific and organ-specific autoimmune diseases

From: Neuromyelitis optica spectrum disorders without and with autoimmune diseases

  NMOSD   NMOSD with autoimmune diseases  
Without autoimmune diseases (n = 115) With autoimmune diseases (n = 40) P Non-organ-specific (n = 22) Organ-specific (n = 18) P
CSF Index       
WBC (106) 6 (0, 140) 10 (0, 48) 0.002* 12 (2, 48) 9.5 (0, 46) 0.307
Protein (g/l) 0.22 (0.06, 1.64) 0.27 (0.12, 0.80) 0.017* 0.27 (0.19, 0.80) 0.32 (0.12, 0.72) 0.754
Glucose (mmol/l) 3.47 ± 0.70 3.11 ± 0.94 0.012* 2.88 ± 0.23 3.41 ± 1.59 0.075
Chloride (mmol/l) 126.3 ± 5.1 126.6 ± 2.8 0.657 126.3 ± 6.9 127.0 ± 9.7 0.434
OCB, n (%) 6 (5.2%) 3 (7.5%) 0.595 2 (9.1%) 1 (5.6%) 1.000
Serums Index       
CRP (mg/l) 2.33 ± 4.37 5.63 ± 7.62 0.001* 2.16 (0.00, 26.09) 0.80 (0.10, 15.00) 0.289
ESR (mm/H) 12.90 ± 7.89 14.04 ± 13.39 0.519 10.5 (1.3, 50.0) 7.00 (3.0, 24.0) 0.414
NMO-IgG, n (%) 71 (67.0%) 32 (80.0%) 0.120 18 (81.8%) 14 (77.8%) 0.751
ANA, n (%) 16 (13.9%) 20 (50.0%) <0.001** 18 (81.8%) 2 (11.1%) <0.001**
SSA, n (%) 2 (1.7%) 20 (50.0%) <0.001** 20 (90.9%) 0 (00.0%) <0.001**
SSB, n (%) 1 (0.9%) 11 (27.5%) <0.001** 11 (50.0%) 0 (00.0%) 0.002*
RF, n (%) 2 (1.7%) 3 (7.5%) 0.075 2 (9.10%) 1 (5.60%) 1.000
Ds-DNA, n (%) 0 (0.0%) 5 (12.5%) 0.001* 5 (22.7%) 0 (00.0%) 0.053
AnuA, n (%) 0 (0.0%) 3 (7.5%) 0.021* 3 (13.6%) 0 (00.0%) 0.305
AHA, n (%) 0 (0.0%) 1 (2.5%) 0.579 1 (4.5%) 0 (00.0%) 1.000
RNP, n (%) 0 (0.0%) 2 (5.0%) 0.110 2 (9.1%) 0 (00.0%) 0.492
Sm, n (%) 0 (0.0%) 3 (7.5%) 0.021* 3 (13.6%) 0 (00.0%) 0.305
Jo-1, n (%) 0 (00.0%) 0 (00.0%) - 0 (00.0%) 0 (00.0%) -
Scl-70, n (%) 0 (00.0%) 0 (00.0%) - 0 (00.0%) 0 (00.0%) -
ANCA, n (%) 0 (00.0%) 0 (00.0%) - 0 (00.0%) 0 (00.0%) -
Rib-P, n (%) 0 (0.0%) 2 (5.0%) 0.110 2 (9.1%) 0 (00.0%) 0.492
AKA, n (%) 0 (00.0%) 0 (00.0%) - 0 (00.0%) 0 (00.0%) -
RA33, n (%) 0 (00.0%) 0 (00.0%) - 0 (00.0%) 0 (00.0%) -
CCP, n (%) 0 (00.0%) 0 (00.0%) - 0 (00.0%) 0 (00.0%) -
IgG (g/l) 12.46 ± 4.95 18.33 ± 0.82 <0.001** 14.18 (7.00, 38.80) 12.61 (7.00, 33.22) 0.765
IgA (g/l) 1.41 ± 0.40 1.51 ± 4.95 0.310 1.30 (0.45, 3.60) 1.28 (0.56, 2.15) 0.142
IgM (g/l) 1.15 ± 0.37 1.06 ± 0.38 0.169 1.14 (0.45, 1.75) 0.97 (0.58, 1.99) 0.454
C3 (g/l) 1.09 ± 0.24 1.04 ± 0.39 0.334 1.06 ± 0.17 1.01 ± 0.13 0.667
C4 (g/l) 0.23 ± 0.15 0.19 ± 0.15 0.116 0.15 (0.04, 0.93) 0.15 (0.03, 0.32) 0.935
CH50 (U/ml) 44.11 ± 12.80 39.60 ± 17.12 0.082 41.50 (10.00, 66.00) 33.00 (19.00, 61.00) 0.549
TPO (U/ml) 54.46 ± 72.57 86.02 ± 124.90 0.055 29.3 (5.7, 60.0) 99.9 (11.7, 533.1) 0.019*
TG (U/ml) 42.82 ± 54.46 91.83 ± 127.25 0.001* 34.05(10.11, 97.14) 82.10 (1.99, 500.00) 0.003*
T3 (nmol/l) 1.96 ± 1.60 4.01 ± 13.72 0.114 1.99 (0.66, 2.45) 1.20 (0.70, 88.08) 1.000
T4 (nmol/l) 97.47 ± 25.95 120.95 ± 65.17 0.002* 106.5 (76.9, 170.0) 94.8 (11.7, 363.6) 0.765
FT3 (pmol/l) 4.07 ± 0.97 4.45 ± 3.31 0.273 4.16 (2.59, 5.47) 3.89 (1.03, 23.98) 0.903
FT4 (pmol/l) 15.62 ± 4.67 20.21 ± 15.91 0.006* 17.06 (10.89, 22.92) 17.18 (8.60, 99.25) 0.663
TSH (uIU/ml) 1.91 ± 2.48 2.85 ± 6.05 0.169 1.93 (0.42, 4.02) 0.98 (0.01,36.50) 0.149
  1. Abbreviations: AHA anti-histone antibody, AKA anti-keratin antibodies, ANA antinuclear antibodies, ANCA anti-neutrophil cytoplasmic antibodies, ANuA anti-nucleosome antibody, C complements, CCP anti-cytosolic carboxypeptidase antibodies, CH50 50% complement hemolysis, CRP C-reactive protein, CSF cerebrospinal fluid, Ds-DNA anti-double stranded DNA antibodies, ESR erythrocyte sedimentation rate, FT3 free triiodothyronine, FT4 free thyroxin, IgG immunoglobulin G, Jo-1 anti-Jo-1 antibodies, NMO-IgG neuromyelitis optica immunoglobulin G, NMOSD neuromyelitis optica spectrum disorders, OCB oligoclonal banding, RA33 anti-RA33 antibodies, RF rheumatoid factor, Rib-P anti-ribosomal P protein antibodies, RNP anti-ribonucleoprotein antibodies, Scl-70 anti-topoisomerase I antibodies, Sm anti-Sm antibodies, SSA Anti-SSA/Ro antibodies, SSB anti-SSB/La antibodies, T3 triiodothyronine, T4 thyroxine, TG anti-thyroglobulin antibodies, TSH thyroid-stimulating hormone, TPO anti-thyroid peroxidase antibodies, WBC white blood cell.
  2. **p < 0.001, *p < 0.05.