Table 3 The genotype frequencies of MMP polymorphisms according to age of participants
Age <18 | Age <18 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Characteristic | Control (n = 102) | Moyamoya (n = 56) | AOR (95% CI) | P a | P b | Control (n = 141) | Moyamoya (n = 51) | AOR (95% CI) | P a | P b |
MMP-2 -1575G > A | ||||||||||
GG | 88 (86.3) | 46 (82.1) | 1.00 (reference) | 122 (86.5) | 46 (90.2) | 1.00 (reference) | ||||
GA | 14 (13.7) | 10 (17.9) | 1.32 (0.54-3.23) | 0.55 | 0.55 | 19 (13.5) | 5 (9.8) | 0.73 (0.26-2.08) | 0.56 | 0.56 |
AA | 0 (0.0) | 0 (0.0) | NA | NA | 0 (0.0) | 0 (0.0) | NA | NA | ||
Dominant (GG vs. GA + AA) | 1.32 (0.54-3.23) | 0.55 | 0.55 | 0.73 (0.26-2.08) | 0.56 | 0.56 | ||||
Recessive (GG + GA vs. AA) | NA | NA | NA | NA | ||||||
MMP-2 -1306C > T | ||||||||||
CC | 90 (88.2) | 53 (94.6) | 1.00 (reference) | 132 (93.6) | 46 (90.2) | 1.00 (reference) | ||||
CT | 12 (11.8) | 3 (5.4) | 0.44 (0.12-1.65) | 0.22 | 0.22 | 9 (6.4) | 5 (9.8) | 1.63 (0.51-5.17) | 0.41 | 0.41 |
TT | 0 (0.0) | 0 (0.0) | NA | NA | 0 (0.0) | 0 (0.0) | NA | NA | ||
Dominant (CC vs. CT + TT) | 0.44 (0.12-1.65) | 0.22 | 0.22 | 1.63 (0.51-5.17) | 0.41 | 0.41 | ||||
Recessive (CC + CT vs. TT) | NA | NA | NA | NA | ||||||
MMP-3 -1171 5a/6a | ||||||||||
6a6a | 76 (74.5) | 43 (76.8) | 1.000 (reference) | 111 (78.7) | 35 (68.6) | 1.00 (reference) | ||||
6a5a | 24 (23.5) | 10 (17.9) | 0.73 (0.32-1.69) | 0.46 | 0.61 | 27 (19.1) | 13 (25.5) | 1.52 (0.71-3.27) | 0.28 | 0.28 |
5a5a | 2 (2.0) | 3 (5.4) | 3.03 (0.47-19.31) | 0.24 | 0.48 | 3 (2.1) | 3 (5.9) | 3.17 (0.61-16.45) | 0.17 | 0.28 |
Dominant (6a6a vs. 6a5a + 5a5a) | 0.90 (0.42-1.95) | 0.80 | 0.80 | 1.69 (0.82-3.46) | 0.15 | 0.28 | ||||
Recessive (6a6a + 6a5a vs. 5a5a) | 3.55 (0.56-22.60) | 0.18 | 0.48 | 2.89 (0.56-14.94) | 0.21 | 0.28 | ||||
MMP-9 -1562C > T | ||||||||||
CC | 79 (77.5) | 45 (80.4) | 1.00 (reference) | 116 (82.3) | 40 (78.4) | 1.00 (reference) | ||||
CT | 22 (21.6) | 9 (16.1) | 0.62 (0.257-1.493) | 0.29 | 0.39 | 25 (17.7) | 10 (19.6) | 1.22 (0.54-2.79) | 0.63 | 0.63 |
TT | 1 (1.0) | 2 (3.6) | 3.79 (0.33-43.80) | 0.29 | 0.39 | 0 (0.0) | 1 (2.0) | NA | NA | |
Dominant (CC vs. CT + TT) | 0.75 (0.33-1.71) | 0.49 | 0.49 | 1.34 (0.60-3.00) | 0.47 | 0.63 | ||||
Recessive (CC + CT vs. TT) | 4.24 (0.37-48.86) | 0.25 | 0.39 | NA | NA | |||||
MMP-9 Q279R | ||||||||||
GG | 41 (40.2) | 29 (51.8) | 1.000 (reference) | 59 (41.8) | 27 (52.9) | 1.00 (reference) | ||||
GA | 52 (51.0) | 25 (44.6) | 0.70 (0.35-1.38) | 0.30 | 0.30 | 68 (48.2) | 21 (41.2) | 0.65 (0.33-1.29) | 0.22 | 0.29 |
AA | 9 (8.8) | 2 (3.6) | 0.25 (0.05-1.29) | 0.10 | 0.30 | 14 (9.9) | 3 (5.9) | 0.41 (0.10-1.60) | 0.20 | 0.29 |
Dominant (GG vs. GA + AA) | 0.63 (0.32-1.24) | 0.19 | 0.30 | 0.62 (0.32-1.18) | 0.15 | 0.29 | ||||
Recessive (GG + GA vs. AA) | 0.38 (0.08-1.83) | 0.23 | 0.30 | 0.52 (0.14-1.92) | 0.33 | 0.33 | ||||