Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke

Table 2 Analysis of association between ischemic stroke risk and ten APOD and SIGMAR1 SNPs

SNP*	Allele pair	Control subj. number of genotypes	IS patients number of genotypes	Crude OR (95% CI)	Multiple LR** OR (95% CI)
*SIGMAR1*:
rs11559048	CC	1530	2695	0.51 (0.21-1.26)	0.58 (0.91-1.20)
	CT	8	9	P = 0.145	P = 0.491
	TT	1	-
rs1800866	TT	1128	2141	1.03 (0.92-1.16)	1.02 (0.90-1.16)
	TG	401	795	P = 0.615	P = 0.768
	GG	46	88
rs12001648	CC	1393	2420	0.95 (0.79-1.15)	0.85 (0.70-1.04)
	CT	165	286	P = 0.595	P = 0.120
	TT	9	8
rs7036351	GG	1130	1944	1.03 (0.91-1.16)	1.02 (0.89-1.16)
	GA	399	693	P = 0.675	P = 0.789
	AA	40	77
rs3808873	GG	833	1475	1.00 (0.89-1.11)	0.98 (0.88-1.10)
	GA	491	887	P = 0.950	P = 0.779
	AA	91	153
*APOD* :***
rs76929107	CC	1540	2943	1.06 (0.74-1.51)	1.10 (0.75-1.59)
	CT	44	91	P = 0.761	P = 0.634
	TT	1	1
rs5952	TT	1548	2710	1.90 (0.52-6.92)	2.23 (0.57-8.75)
	TC	3	10	P = 0.329	P = 0.251
	CC	-	-
rs34697430	GG	435	769	1.00 (0.92-1.09)	1.01 (0.92-1.11)
	GA	784	1317	P = 0.966	P = 0.895
	AA	349	623
rs7659	AA	803	1306	1.11 (1.01-1.22)	1.12 (1.01-1.25)
	AG	617	1177	P = 0.038	P = 0.029
	GG	130	240
rs823510	TT	880	1576	0.99 (0.89-1.09)	0.99 (0.89-1.11)
	TG	590	981	P = 0.805	P = 0.884
	GG	82	164

*)All genotypes were conforming to the Hardy-Weinberg equilibrium criterion (with P = 0.093 or more when using a chi-square test on the control subjects), except for rs11559048 that showed a significant Hardy-Weinberg disequilibrium (P < 0.001).
**)ORs obtained by multiple logistic regression analysis controlling for covariates age, gender, diabetes mellitus, hypertension and current smoking.
***)Two additional APOD encoding SNPs, rs5954 and rs5955, were genotyped but not included in this study due to monomorphic traits.

ISSN: 1471-2377