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Table 2 Analysis of association between ischemic stroke risk and ten APOD and SIGMAR1 SNPs

From: Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke

SNP* Allele pair Control subj. number of genotypes IS patients number of genotypes Crude OR (95% CI) Multiple LR** OR (95% CI)
SIGMAR1:      
rs11559048 CC 1530 2695 0.51 (0.21-1.26) 0.58 (0.91-1.20)
  CT 8 9 P = 0.145 P = 0.491
  TT 1 -   
rs1800866 TT 1128 2141 1.03 (0.92-1.16) 1.02 (0.90-1.16)
  TG 401 795 P = 0.615 P = 0.768
  GG 46 88   
rs12001648 CC 1393 2420 0.95 (0.79-1.15) 0.85 (0.70-1.04)
  CT 165 286 P = 0.595 P = 0.120
  TT 9 8   
rs7036351 GG 1130 1944 1.03 (0.91-1.16) 1.02 (0.89-1.16)
  GA 399 693 P = 0.675 P = 0.789
  AA 40 77   
rs3808873 GG 833 1475 1.00 (0.89-1.11) 0.98 (0.88-1.10)
  GA 491 887 P = 0.950 P = 0.779
  AA 91 153   
APOD :***      
rs76929107 CC 1540 2943 1.06 (0.74-1.51) 1.10 (0.75-1.59)
  CT 44 91 P = 0.761 P = 0.634
  TT 1 1   
rs5952 TT 1548 2710 1.90 (0.52-6.92) 2.23 (0.57-8.75)
  TC 3 10 P = 0.329 P = 0.251
  CC - -   
rs34697430 GG 435 769 1.00 (0.92-1.09) 1.01 (0.92-1.11)
  GA 784 1317 P = 0.966 P = 0.895
  AA 349 623   
rs7659 AA 803 1306 1.11 (1.01-1.22) 1.12 (1.01-1.25)
  AG 617 1177 P = 0.038 P = 0.029
  GG 130 240   
rs823510 TT 880 1576 0.99 (0.89-1.09) 0.99 (0.89-1.11)
  TG 590 981 P = 0.805 P = 0.884
  GG 82 164   
  1. *)All genotypes were conforming to the Hardy-Weinberg equilibrium criterion (with P = 0.093 or more when using a chi-square test on the control subjects), except for rs11559048 that showed a significant Hardy-Weinberg disequilibrium (P < 0.001).
  2. **)ORs obtained by multiple logistic regression analysis controlling for covariates age, gender, diabetes mellitus, hypertension and current smoking.
  3. ***)Two additional APOD encoding SNPs, rs5954 and rs5955, were genotyped but not included in this study due to monomorphic traits.