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Table 5 Analysis of association between outcome after stroke (shown by modified Rankin Scale, mRS) and ten APOD and SIGMAR1 SNPs

From: Variations in apolipoprotein D and sigma non-opioid intracellular receptor 1 genes with relation to risk, severity and outcome of ischemic stroke

  Deceased patientsare notincluded in mRS: Deceased patientsareincluded in mRS:
Ordinal score: Dichotomous indicator for dependence of support: Ordinal score: Dichotomous indicator for dependence of support:
SNP Estimated Spearman’s Rho P-value Simple logistic regression Multiple logistic regression Estimated Spearman’s Rho P-value Simple logistic regression Multiple logistic regression
OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value
SIGMAR1:             
rs11559048 0.045 0.081 3.35 (0.80-14.1) 0.099 2.75 (0.49-15.3) 0.249 0.026 0.286 2.64 (0.63-11.1) 0.185 2.29 (0.38-13.7) 0.364
rs1800866 0.011 0.655 1.13 (0.93-1.37) 0.231 1.10 (0.88-1.36) 0.404 0.004 0.872 1.08 (0.90-1.30) 0.402 1.06 (0.85-1.31) 0.612
rs12001648 -0.012 0.631 0.94 (0.67-1.32) 0.712 0.77 (0.53-1.11) 0.165 -0.001 0.963 0.98 (0.72-1.34) 0.892 0.75 (0.53-1.07) 0.115
rs7036351 0.006 0.817 1.10 (0.89-1.33) 0.390 1.03 (0.83-1.29) 0.781 -0.007 0.772 1.04 (0.86-1.25) 0.722 0.97 (0.79-1.21) 0.810
rs3808873 0.021 0.436 1.08 (0.90-1.29) 0.392 1.11 (0.91-1.35) 0.290 0.012 0.636 1.05 (0.89-1.24) 0.598 1.07 (0.89-1.30) 0.457
APOD:             
rs76929107 0.002 0.947 0.98 (0.54-1.78) 0.943 0.95 (0.49-1.82) 0.868 -0.013 0.582 0.87 (0.49-1.54) 0.623 0.92 (0.48-1.73) 0.790
rs5952 0.016 0.520 1.98 (0.28-14.1) 0.494 2.90 (0.32-26.7) 0.346 0.025 0.306 2.35 (0.39-14.1) 0.350 3.09 (0.35-27.5) 0.312
rs34697430 -0.019 0.460 0.91 (0.78-1.06) 0.221 0.91 (0.77-1.07) 0.243 0.002 0.946 0.96 (0.83-1.10) 0.514 0.92 (0.79-1.08) 0.295
rs7659 0.002 0.929 1.03 (0.88-1.22) 0.684 0.98 (0.82-1.17) 0.832 -0.005 0.846 1.02 (0.87-1.18) 0.842 0.96 (0.81-1.14) 0.665
rs823510 0.012 0.653 1.01 (0.85-1.21) 0.882 1.02 (0.84-1.23) 0.871 -0.008 0.742 0.97 (0.82-1.14) 0.696 0.97 (0.81-1.17) 0.764
  1. Ischemic stroke patients from Lund Stroke Register and the Sahlgenska Academy Study on Ischemic Stroke.
  2. mRS = modified Rankin Scale. Ordinal score comprises distinguishable categories 0–2, 3, 4, 5 and, if deceased patients are included, also category 6. Correspondingly, dichotomous indicator comprises categories 0–2 as control subjects and category 3 or above as cases.