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Table 2 Associations between IRT-derived disability scores and prevalence of unemployment after adjustment for patient characteristics

From: Item response theory-based measure of global disability in multiple sclerosis derived from the Performance Scales and related items

Characteristic

 

Bifactor model

Unidimensional model

 

N (%)

PRa(95% CI)

PRa(95% CI)

PRa(95% CI)

Global disability (scaled score, S)b

    

S ≤ 33.3

562 (14.3)

1.0c,d

1.0c,d

1.0c,e

33.3 < S ≤ 50

1390 (35.4)

1.50 (1.28, 1.77)

1.83 (1.55, 2.17)

1.73 (1.46, 2.04)

50 < S ≤ 66.7

1428 (36.4)

2.14 (1.83, 2.51)

2.75 (2.34, 3.23)

2.87 (2.46, 3.36)

S > 66.7

546 (13.9)

2.74 (2.33, 3.22)

3.66 (3.12, 4.30)

3.79 (3.24, 4.43)

Residual physical disability (scaled score, S)b

    

S ≤ 33.3

257 (6.5)

1.0c,d

  

33.3 < S ≤ 50

1876 (47.8)

1.17 (.99, 1.38)

  

50 < S ≤ 66.7

1339 (34.1)

1.56 (1.32, 1.84)

  

S > 66.7

454 (11.6)

2.02 (1.70, 2.40)

  

Residual mental disability (scaled score, S)b

    

S ≤ 33.3

236 (6.0)

1.0c,d

  

33.3 < S ≤ 50

1678 (42.7)

1.11 (.98, 1.26)

  

50 < S ≤ 66.7

1783 (45.5)

1.35 (1.19, 1.52)

  

S > 66.7

229 (5.8)

1.53 (1.32, 1.78)

  

Disease duration (y.)

    

≤ 10

1713 (43.6)

1.0c

1.0c

1.0c

11 – 20

1109 (28.3)

1.06 (.98, 1.14)

1.10 (1.02, 1.19)

1.09 (1.01, 1.18)

≥ 21

1104 (28.1)

1.21 (1.13, 1.30)

1.27 (1.18, 1.37)

1.25 (1.16, 1.34)

Age at assessment (y.)

    

≤ 35

749 (19.1)

1.0c

1.0c

1.0c

36 – 55

1760 (44.8)

1.01 (.91, 1.11)

1.03 (.93, 1.14)

1.02 (.92, 1.13)

≥ 56

1417 (36.1)

1.22 (1.10, 1.35)

1.31 (1.18, 1.45)

1.28 (1.16, 1.42)

Gender

    

Female

3102 (79.4)

1.0c

1.0c

1.0c

Male

803 (20.6)

1.04 (.98, 1.10)

1.08 (1.02, 1.15)

1.08 (1.01, 1.14)

Race/Ethnicity

    

White

3491 (90.2)

1.0c

1.0c

1.0c

African American

132 (3.4)

1.14 (.99, 1.31)

1.16 (1.00, 1.33)

1.14 (.99, 1.31)

Hispanic/Latino

120 (3.1)

1.14 (.97, 1.34)

1.11 (.95, 1.31)

1.12 (.94, 1.31)

Native American

76 (2.0)

1.11 (.95, 1.30)

1.10 (.95, 1.28)

1.09 (.94, 1.25)

Other

49 (1.3)

1.23 (1.00, 1.52)

1.24 (1.00, 1.52)

1.16 (.94, 1.43)

Disease modifying therapy

    

Yes

2614 (66.6)

1.0c

1.0c

1.0c

No

1312 (33.4)

1.05 (.99, 1.11)

1.08 (1.02, 1.14)

1.06 (1.01, 1.13)

Year of assessment

    

2003-2005

1640 (41.8)

1.0c

1.0c

1.0c

2006-2008

957 (24.4)

1.01 (.94, 1.08)

1.01 (.94, 1.09)

1.02 (.95, 1.09)

2009-2011

1329 (33.8)

1.04 (.98, 1.11)

1.01 (.94, 1.07)

1.01 (.95, 1.08)

  1. aPR stands for “prevalence ratio”. Because prevalence of unemployment was high, we performed Poisson regression with robust variance estimation instead of logistic regression to obtain unbiased prevalence ratio estimates [30].
  2. bIRT scores scaled to have mean 50 and SD 15 in the NARCOMS sample.
  3. cReference category.
  4. dBayesian Expected a posteriori (EAP) estimates of disability (i.e., “IRT pattern scores”).
  5. eEAP summed-score estimates of disability (i.e., “IRT summed scores”).