Skip to main content

Table 1 Cam-CAN exclusion criteria: conditions assessed at stage 1 interview that could result in exclusion, listed by category

From: The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: a cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing

Exclusion category Exclusion criteria
Cognitive health MMSE score 24 or less (calculated in interview)
  Missing MMSE scores (assumed to be 24 or less)
  Severe memory defect
  Consent difficulties for next stage
Communication difficulties Hearing problems (difficulty completing interview with hearing aid; inability to hear 35 db at 1000 Hz in either ear in interview functional hearing screening; hearing aid that cannot be removed)
  Insufficient English language (native language not English and not bilingual English from birth)
  Vision difficulties (correct near vision of 20/100 or worse with both eyes)
Medical problems (self-report of diagnosis) Dementia diagnosis/Alzheimer's Disease
  Parkinson's disease
  Motor Neurone disease
  Multiple Sclerosis
  Cancer (history of brain tumour or chemotherapy/radiotherapy for any cancer in last 6 months)
  Stroke
  Encephalitis
  Meningitis
  Epilepsy
  Head injury with serious results (coma, unconscious for >2 hrs, or skull fracture)
  Recently diagnosed or uncontrolled high blood pressure
  Pregnancy or trying to become pregnant
  Current serious psychiatric conditions (bipolar disorder, schizophrenia, or psychosis)
Mobility problems Restricted mobility which would prevent further participation
  Inability to walk 10 metres
Substance abuse Past or current treatment for drug abuse
  Current drug usage
  Refusal to answer substance abuse questions
Specific MRI/MEG safety and comfort exclusions Heart operation
  Blood vessel procedure or device (carotid artery vascular clamp; venous umbrella; stent, filter or coil; Swan-Ganz catheter; vascular access ports or catheters)
  Neurostimulator or spinal fusion stimulator
  Electrodes on body, head or brain
  Pump, Implant or pacemaker
  Brain Operation
  Metal splinters in eye, head or ear
  Shrapnel, buckshot or bullet in body
  Wire sutures or surgical staples
  Artificial joints that are MRI incompatible (jaw/maxillary reconstruction; shoulder prosthesis; any other joint replacement surgery in the last 3 months)
  Bone fixation rods or plates in jaw, head, shoulders or spine
  Non-removable dental brace
  Non-removable prosthesis or removable eye prosthesis
  Inability to lie flat for an hour
  Claustrophobia
  Body piercings that cannot be removed
  IUD that is MRI incompatible
  Transdermal delivery patches that cannot be removed
  Tattoos on head face or neck