Table 1 Cam-CAN exclusion criteria: conditions assessed at stage 1 interview that could result in exclusion, listed by category

Cognitive health

MMSE score 24 or less (calculated in interview)

Missing MMSE scores (assumed to be 24 or less)

Severe memory defect

Consent difficulties for next stage

Communication difficulties

Hearing problems (difficulty completing interview with hearing aid; inability to hear 35 db at 1000 Hz in either ear in interview functional hearing screening; hearing aid that cannot be removed)

Insufficient English language (native language not English and not bilingual English from birth)

Vision difficulties (correct near vision of 20/100 or worse with both eyes)

Medical problems (self-report of diagnosis)

Dementia diagnosis/Alzheimer's Disease

Parkinson's disease

Motor Neurone disease

Multiple Sclerosis

Cancer (history of brain tumour or chemotherapy/radiotherapy for any cancer in last 6 months)

Stroke

Encephalitis

Meningitis

Epilepsy

Head injury with serious results (coma, unconscious for >2 hrs, or skull fracture)

Recently diagnosed or uncontrolled high blood pressure

Pregnancy or trying to become pregnant

Current serious psychiatric conditions (bipolar disorder, schizophrenia, or psychosis)

Mobility problems

Restricted mobility which would prevent further participation

Inability to walk 10 metres

Substance abuse

Past or current treatment for drug abuse

Current drug usage

Refusal to answer substance abuse questions

Specific MRI/MEG safety and comfort exclusions

Heart operation

Blood vessel procedure or device (carotid artery vascular clamp; venous umbrella; stent, filter or coil; Swan-Ganz catheter; vascular access ports or catheters)

Neurostimulator or spinal fusion stimulator

Electrodes on body, head or brain

Pump, Implant or pacemaker

Brain Operation

Metal splinters in eye, head or ear

Shrapnel, buckshot or bullet in body

Wire sutures or surgical staples

Artificial joints that are MRI incompatible (jaw/maxillary reconstruction; shoulder prosthesis; any other joint replacement surgery in the last 3 months)

Bone fixation rods or plates in jaw, head, shoulders or spine

Non-removable dental brace

Non-removable prosthesis or removable eye prosthesis

Inability to lie flat for an hour

Claustrophobia

Body piercings that cannot be removed

IUD that is MRI incompatible

Transdermal delivery patches that cannot be removed

Tattoos on head face or neck