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Table 2 Brain magnetic resonance imaging findings of evaluable NMOSD and MS patients

From: Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients

  NMOSD (n = 25) MS (n = 29) P -value
Number of MRI studies 40 54  
Location of lesions
  Juxtacortical region (%) 15(60) 20(69) 0.573
  Subcortical region (%) 19(76) 21(73) 1.000
  Basal ganglion (%) 15(60) 16(55) 0.787
  Periventricular region (%) 15(60) 22(76) 0.250
  Temporal lobe (%) 9(36) 13(45) 0.585
  Infra-tentorium (%) 10(40) 20(69) 0.054
  Central/dorsal medulla (%) 4(16) 7(24) 0.517
  Corpus callosum (%) 1(4) 10(34) 0.007*
  Periaqueductal gray(%) 8(32) 10(34) 1.000
  Unilateral (%) 2(8) 8(28) 0.086
  Bilateral (%) 6(24) 2(7) 0.125
  Hypothalamus (%) 5(20) 2(7) 0.229
  Fit McDonald criteria (DIS) 15(60) 22(76) 0.250
  Fit Matthews criteria 15(60) 23(79) 0.145
Morphological patterns
  U fiber lesion (%) 12(48) 18(62) 0.411
  Dawson finger lesion (%) 11(44) 16(55) 0.586
  Tumefactive lesion >3 cm (%) 2(8) 1(3) 0.591
  Punctate lesion (%) 16(64) 8(28) 0.013*
  Linear ependymal lesion (%) 7(28) 0(0) 0.003*
  Ependymal dot lesion (%) 3(12) 10(34) 0.065
  1. NMOSD: neuromyelitis optica spectrum disorder; MS: multiple sclerosis; McDonald criteria (DIS): 2010 McDonald dissemination in space criteria.
  2. *Statistically significant difference between NMOSD and MS.
  3. The Matthews criteria used for separating MS from NMOSD: at least 1 lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe; or the presence of a subcortical U-fiber lesion or a Dawson finger-type lesion.