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Table 2 Brain magnetic resonance imaging findings of evaluable NMOSD and MS patients

From: Comparison between the cranial magnetic resonance imaging features of neuromyelitis optica spectrum disorder versus multiple sclerosis in Taiwanese patients

 

NMOSD (n = 25)

MS (n = 29)

P -value

Number of MRI studies

40

54

 

Location of lesions

  Juxtacortical region (%)

15(60)

20(69)

0.573

  Subcortical region (%)

19(76)

21(73)

1.000

  Basal ganglion (%)

15(60)

16(55)

0.787

  Periventricular region (%)

15(60)

22(76)

0.250

  Temporal lobe (%)

9(36)

13(45)

0.585

  Infra-tentorium (%)

10(40)

20(69)

0.054

  Central/dorsal medulla (%)

4(16)

7(24)

0.517

  Corpus callosum (%)

1(4)

10(34)

0.007*

  Periaqueductal gray(%)

8(32)

10(34)

1.000

  Unilateral (%)

2(8)

8(28)

0.086

  Bilateral (%)

6(24)

2(7)

0.125

  Hypothalamus (%)

5(20)

2(7)

0.229

  Fit McDonald criteria (DIS)

15(60)

22(76)

0.250

  Fit Matthews criteria†

15(60)

23(79)

0.145

Morphological patterns

  U fiber lesion (%)

12(48)

18(62)

0.411

  Dawson finger lesion (%)

11(44)

16(55)

0.586

  Tumefactive lesion >3 cm (%)

2(8)

1(3)

0.591

  Punctate lesion (%)

16(64)

8(28)

0.013*

  Linear ependymal lesion (%)

7(28)

0(0)

0.003*

  Ependymal dot lesion (%)

3(12)

10(34)

0.065

  1. NMOSD: neuromyelitis optica spectrum disorder; MS: multiple sclerosis; McDonald criteria (DIS): 2010 McDonald dissemination in space criteria.
  2. *Statistically significant difference between NMOSD and MS.
  3. †The Matthews criteria used for separating MS from NMOSD: at least 1 lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe; or the presence of a subcortical U-fiber lesion or a Dawson finger-type lesion.
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BMC Neurology

ISSN: 1471-2377

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