Figure 1
From: An open-label pilot trial of minocycline in children as a treatment for Angelman syndrome
Minocycline restores the synaptic plasticity defect in the AS mouse model. 3-month-old UBE3A maternal deficient (AS) mice show increase in long-term potentiation (LTP) after 21Â days of treatment with minocycline. Field extracellular postsynaptic potentials (fEPSPs) were recorded and their slopes are conveyed as a percentage of the pre-theta burst stimulation (TBS) baseline. Representative traces before (bold) and 30Â minutes after TBS are shown for saline treated (control) and minocycline treated AS mice.