An open-label pilot trial of minocycline in children as a treatment for Angelman syndrome

BMC Neurology

Table 2 Neuropsychological outcome measures

Bayley Scales of Infant and Toddler Development, 3rd Edition
	Cognitive	Communication	Language		Motor		Self
			Receptive	Expressive	Gross	Fine	Care	Direction
T1	26.4 ± 2.48	18.9 ± 1.60	13.4 ± 0.61	10.1 ± 0.76	41.3 ± 1.69	19.4 ± 1.05	37.8 ± 1.81	33.8 ± 2.24
T2	31.7 ± 1.83	22.8 ± 1.69	13.7 ± 0.81	11.8 ± 0.75	40.5 ± 1.60	19.8 ± 1.47	40.6 ± 1.84	*38.1 ± 1.98
T3	30.7 ± 2.09	*23.5 ± 1.88	13.8 ± 0.68	11.2 ± 0.68	42.8 ± 1.12	^†22.4 ± 1.5	40.0 ± 1.99	*39.5 ± 1.94
η²	0.05	0.05	0.002	0.04	0.02	0.03	0.02	0.06
Vineland Adaptive Behavior Scales, 2nd Edition
	Maladaptive Behavior		Communication		Motor		Daily Living Skills
	Internal	External	Receptive	Expressive	Gross	Fine	Personal	Domestic
T1	6.7 ± 0.44	5.5 ± 0.58	30.3 ± 1.62	41.8 ± 3.02	48.3 ± 3.27	99.0 ± 7.12	53.8 ± 5.61	2.6 ± 0.95
T2	5.5 ± 0.47	4.7 ± 0.57	*36.4 ± 2.42	44.3 ± 3.23	48.9 ± 3.32	101.2 ± 7.5	59.1 ± 5.75	3.8 ± 1.49
T3	5.7 ± 0.52	6.0 ± 1.25	33.9 ± 2.25	43.8 ± 2.58	49.4 ± 3.25	95.4 ± 7.84	56.4 ± 4.95	2.7 ± 0.92
η²	0.05	0.02	0.06	0.06	0.001	0.004	0.007	0.01
Preschool Language Scale, 4th Edition
	Auditory Comprehension		Total Language			Expressive Communication
T1	17.64 ± 0.68		34.20 ± 1.58			16.3 ± 1.14
T2	18.25 ± 0.58		34.88 ± 1.36			16.6 ± 0.94
T3	*20.48 ± 0.71		*38.83 ± 1.34			17.5 ± 0.71
η²	0.13		0.08			0.001

Mean ± Standard Error.
η² (Partial Eta squared) is a measure of effect size. 0.01 suggests a small effect, 0.06 a medium effect and 0.14 a large effect.
*p < 0.05 when the time point is compared to T1 (baseline).
†p < 0.05 when the time point is compared to T2 (after treatment with minocycline).

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