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Table 2 Neuropsychological outcome measures

From: An open-label pilot trial of minocycline in children as a treatment for Angelman syndrome

Bayley Scales of Infant and Toddler Development, 3rd Edition
  Cognitive Communication Language Motor Self
    Receptive Expressive Gross Fine Care Direction
T1 26.4 ± 2.48 18.9 ± 1.60 13.4 ± 0.61 10.1 ± 0.76 41.3 ± 1.69 19.4 ± 1.05 37.8 ± 1.81 33.8 ± 2.24
T2 31.7 ± 1.83 22.8 ± 1.69 13.7 ± 0.81 11.8 ± 0.75 40.5 ± 1.60 19.8 ± 1.47 40.6 ± 1.84 *38.1 ± 1.98
T3 30.7 ± 2.09 *23.5 ± 1.88 13.8 ± 0.68 11.2 ± 0.68 42.8 ± 1.12 22.4 ± 1.5 40.0 ± 1.99 *39.5 ± 1.94
η2 0.05 0.05 0.002 0.04 0.02 0.03 0.02 0.06
Vineland Adaptive Behavior Scales, 2nd Edition
  Maladaptive Behavior Communication Motor Daily Living Skills
  Internal External Receptive Expressive Gross Fine Personal Domestic
T1 6.7 ± 0.44 5.5 ± 0.58 30.3 ± 1.62 41.8 ± 3.02 48.3 ± 3.27 99.0 ± 7.12 53.8 ± 5.61 2.6 ± 0.95
T2 5.5 ± 0.47 4.7 ± 0.57 *36.4 ± 2.42 44.3 ± 3.23 48.9 ± 3.32 101.2 ± 7.5 59.1 ± 5.75 3.8 ± 1.49
T3 5.7 ± 0.52 6.0 ± 1.25 33.9 ± 2.25 43.8 ± 2.58 49.4 ± 3.25 95.4 ± 7.84 56.4 ± 4.95 2.7 ± 0.92
η2 0.05 0.02 0.06 0.06 0.001 0.004 0.007 0.01
Preschool Language Scale, 4th Edition
  Auditory Comprehension Total Language Expressive Communication
T1 17.64 ± 0.68 34.20 ± 1.58 16.3 ± 1.14
T2 18.25 ± 0.58 34.88 ± 1.36 16.6 ± 0.94
T3 *20.48 ± 0.71 *38.83 ± 1.34 17.5 ± 0.71
η2 0.13 0.08 0.001
  1. Mean ± Standard Error.
  2. η2 (Partial Eta squared) is a measure of effect size. 0.01 suggests a small effect, 0.06 a medium effect and 0.14 a large effect.
  3. *p < 0.05 when the time point is compared to T1 (baseline).
  4. †p < 0.05 when the time point is compared to T2 (after treatment with minocycline).