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Table 2 Protein changes unique to RIA, UIA, or IA

From: Identification of the soluble form of tyrosine kinase receptor Axl as a potential biomarker for intracranial aneurysm rupture

Protein name

iTRAQ ratios a

Nb

DC

RIA

UIA

Proteins unique to RIA

    

Immune/inflammatory response

    

  Complement C1s subcomponent precursor

1.03 ± 0.10

1.28 ± 0.16

0.96 ± 0.11

4

  Pigment epithelium-derived factor precursor

1.29 ± 0.16

0.76 ± 0.05

1.22 ± 0.25

4

Cell Adhesion

    

  Alcadein alpha-1

1.22 ± 0.17

0.81 ± 0.03

1.32 ± 0.11

2

  Calsyntenin-1 precursor

0.78 ± 0.16

1.20 ± 0.12

0.82 ± 0.08

3

  Contactin 2 precursor

0.93 ± 0.14

1.20 ± 0.08

0.95 ± 0.21

5

  Nectin-like protein 2

1.09 ± 0.15

0.61 ± 0.13

1.62 ± 0.23

3

  Neural cell adhesion molecule 1, 140 kDa isoform precursor

0.88 ± 0.12

0.44 ± 0.14

0.97 ± 0.21

3

Extracellular Matrix

    

  Secretogranin III precursor

0.83 ± 0.05

0.63 ± 0.04

1.00 ± 0.16

3

  Splice isoform 1 of fibrinogen gamma chain precursor

0.96 ± 0.15

1.52 ± 0.19

1.18 ± 0.12

3

  Splice isoform 1 of fibulin-1 precursor

1.03 ± 0.12

0.64 ± 0.11

1.09 ± 0.15

3

Protein synthesis or protein degradation

    

  Hypothetical protein FLJ23322

0.64 ± 0.09

1.43 ± 0.14

0.46 ± 0.05

2

  Hypothetical protein FLJ23757

1.07 ± 0.08

3.79 ± 0.53

0.99 ± 0.10

2

  PREDICTED: KIAA1509

0.64 ± 0.18

1.43 ± 0.11

0.46 ± 0.27

2

  Splice isoform 1 of ecto-ADP-ribosyltransferase 3 precursor

1.20 ± 0.16

3.05 ± 0.31

1.15 ± 0.23

2

  TAR RNA loop binding protein

0.71 ± 0.25

1.50 ± 0.16

1.14 ± 0.08

3

Transport

    

  Afamin precursor

1.18 ± 0.08

1.39 ± 0.05

1.19 ± 0.12

4

  Ceruloplasmin precursor

1.28 ± 0.14

0.76 ± 0.19

0.94 ± 0.19

10

  Neuronal pentraxin I precursor

1.07 ± 0.10

0.67 ± 0.04

0.88 ± 0.03

2

  Serotransferrin precursor

0.98 ± 0.47

0.76 ± 0.50

0.96 ± 0.35

59

Apoptosis or anti-apoptosis

    

AXL receptor tyrosine kinase, isoform 1

1.12 ± 0.11

1.68 ± 0.07

0.87 ± 0.16

2

  Splice isoform 1 of amine oxidase flavin containing domain protein 2

0.88 ± 0.13

0.38 ± 0.14

1.12 ± 0.08

2

  Beta-2-glycoprotein I precursor

0.85 ± 0.14

1.48 ± 0.20

1.09 ± 0.09

4

  Ephrin A1 isoform b precursor

0.75 ± 0.06

1.23 ± 0.03

1.18 ± 0.02

2

  Tyrosine phosphatase zeta polypeptide 2 HTPZP2

1.32 ± 0.21

0.43 ± 0.12

1.20 ± 0.19

2

Cell proliferation/differentiation/migration

 

  Splice isoform 1 of erythrocyte membrane protein band 4.2

0.93 ± 0.09

3.86 ± 0.49

1.53 ± 0.11

2

Signal transduction

    

  XPR1 protein

0.88 ± 0.18

0.38 ± 0.07

1.12 ± 0.15

2

Metabolism

    

  Guanylate binding protein 4

1.26 ± 0.13

0.68 ± 0.10

1.07 ± 0.11

2

  Splice isoform 2 of adenosine kinase

0.88 ± 0.08

0.38 ± 0.15

1.12 ± 0.11

2

  Splice isoform 2 of phospholipid transfer protein precursor

0.71 ± 0.23

1.45 ± 0.07

0.86 ± 0.16

2

Cell structure/cytoskeleton

    

  Nebulin

1.11 ± 0.21

1.74 ± 0.30

1.18 ± 0.09

3

  PREDICTED: dynein, cytoplasmic, heavy polypeptide 2

0.88 ± 0.09

0.38 ± 0.12

1.12 ± 0.16

2

  Splice isoform 3 o myosin Va

0.68 ± 0.29

1.55 ± 0.15

1.14 ± 0.08

3

  Titin

1.08 ± 0.14

0.64 ± 0.07

1.07 ± 0.13

2

Unknown

    

  17-beta hydroxysteroid dehydrogenase

0.80 ± 0.21

1.75 ± 0.23

1.12 ± 0.16

2

  Chromosome 1 open reading frame 27

0.88 ± 0.17

0.38 ± 0.12

1.12 ± 0.16

2

  JRK protein

1.05 ± 0.05

1.77 ± 0.17

0.69 ± 0.06

2

  PREDICTED: KIAA1522 protein

0.60 ± 0.16

1.40 ± 0.20

0.84 ± 0.12

2

  PREDICTED: similar to RIKEN cDNA 1700022C21

0.80 ± 0.21

1.75 ± 0.16

1.12 ± 0.10

2

  Taste receptor type 2 member 7

0.88 ± 0.12

0.38 ± 0.06

1.12 ± 0.04

2

  Zinc finger MYND domain containing protein 19

0.97 ± 0.03

1.31 ± 0.12

0.86 ± 0.08

2

Proteins unique to UIA

    

Immune/inflammatory response

    

  Complement C5 precursor

1.34 ± 0.15

1.09 ± 0.07

0.68 ± 0.05

2

Cell Adhesion

    

  Splice isoform 1 of neogenin precursor

1.05 ± 0.10

1.10 ± 0.14

0.71 ± 0.12

3

Protein synthesis or protein degradation

    

  Hypothetical protein FLJ34458

1.13 ± 0.10

0.94 ± 0.12

0.63 ± 0.03

2

  SERPIND1 protein

1.01 ± 0.15

1.00 ± 0.08

1.21 ± 0.06

4

Transport

    

  Transthyretin precursor

0.95 ± 0.15

0.88 ± 0.07

0.69 ± 0.11

5

Apoptosis or anti-apoptosis

    

  Baculoviral IAP repeat-containing protein 4

1.20 ± 0.11

1.00 ± 0.06

0.47 ± 0.08

2

  Nectin-like protein 2

1.09 ± 0.15

0.61 ± 0.13

1.62 ± 0.23

3

  Nucleolysin TIAR

0.93 ± 0.07

0.88 ± 0.12

0.68 ± 0.06

3

  Splice isoform 2 of signal transducer and activator of transcription 1-alpha/beta

1.13 ± 0.06

0.94 ± 0.03

0.63 ± 0.10

2

Cell proliferation/differentiation/migration

    

  Condensin subunit 2

0.85 ± 0.10

0.87 ± 0.09

0.55 ± 0.08

3

Signal transduction

    

  Grb10 interacting GYF protein 1

1.13 ± 0.05

0.94 ± 0.14

0.63 ± 0.02

2

Metabolism

    

  Vitamin D-binding protein precursor

1.14 ± 0.10

1.06 ± 0.18

1.29 ± 0.09

6

Unknown

    

  JRK protein

1.05 ± 0.05

1.77 ± 0.17

0.69 ± 0.06

2

Proteins changed both in RIA and UIA

    

Immune/inflammatory response

    

  Complement C3 precursor

0.91 ± 0.40

1.28 ± 0.42

1.25 ± 0.33

16

  Splice isoform 2 of interleukin-17E precursor

1.21 ± 0.09

0.62 ± 0.13

0.67 ± 0.12

2

Cell Adhesion

    

  Neurocan core protein precursor

0.91 ± 0.15

0.44 ± 0.10

0.54 ± 0.12

3

  Splice isoform 2 of fibrinogen alpha/alpha-E chain precursor

1.14 ± 0.16

0.56 ± 0.12

0.78 ± 0.13

4

Extracellular Matrix

    

  Extracellular matrix protein 1

1.16 ± 0.12

0.55 ± 0.15

0.69 ± 0.13

3

  Metalloproteinase inhibitor 1 precursor

1.07 ± 0.11

1.25 ± 0.08

1.31 ± 0.12

4

Protein synthesis or protein degradation

    

  Acheron, isoform 1

0.97 ± 0.03

1.31 ± 0.08

1.64 ± 0.16

2

Transport

    

  Apolipoprotein D precursor

1.19 ± 0.08

1.43 ± 0.12

1.47 ± 0.11

3

  Serum albumin precursor

1.08 ± 0.17

1.39 ± 0.11

1.59 ± 0.12

4

Cell proliferation/differentiation/migration

    

  Septin 10 isoform 2

1.08 ± 0.02

1.28 ± 0.05

1.46 ± 0.08

2

Signal transduction

    

  Adrenomedullin 2 precursor

1.08 ± 0.04

1.30 ± 0.07

1.28 ± 0.04

2

  CD59 glycoprotein precursor

0.90 ± 0.07

0.49 ± 0.03

0.64 ± 0.06

2

  Neuronal pentraxin receptor isoform 1

1.00 ± 0.02

0.74 ± 0.05

0.50 ± 0.11

3

Metabolism

    

  Lumican precursor

0.99 ± 0.13

1.57 ± 0.04

1.36 ± 0.13

3

  N-acetylgalactosamine-4-O-sulfotransferase

0.88 ± 0.05

1.21 ± 0.08

1.28 ± 0.07

2

Cell structure/cytoskeleton

    

  Keratin 1

1.49 ± 0.17

0.66 ± 0.07

0.82 ± 0.07

3

  PREDICTED: similar to keratin, type I cytoskeletal 18 (cytokeratin 18) (K18) (CK 18)

1.73 ± 0.28

0.69 ± 0.06

0.76 ± 0.08

2

Unknown

    

  DJ570F3.6

0.69 ± 0.23

2.36 ± 0.36

2.14 ± 0.24

2

  MUF1 protein

1.09 ± 0.08

0.72 ± 0.10

0.72 ± 0.11

3

PREDICTED: hypothetical protein XP_291007

0.97 ± 0.06

0.59 ± 0.04

0.60 ± 0.04

2

  1. aiTRAQ ratios shown as mean ± S.D. obtained by averaging the iTRAQ ratios of individual peptides. The differences between groups were analyzed by one–way ANOVA followed by Newman-Keuls multiple comparison test. bNumbers of identified peptides used for calculating the iTRAQ ratios. The iTRAQ ratio in bold showed significant differences compared to the other group(s) (p < 0.05).
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BMC Neurology

ISSN: 1471-2377

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