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Table 3 Outcomes before and after intravenous immunoglobulin treatment of patients with postpolio syndrome

From: Intravenous immunoglobulin for postpolio syndrome: a systematic review and meta-analysis

Study Assessment Results
Bertolasi [2013] [14] SF-36, 6MWT, muscle strength, FSS, and VAS at 2 and 4 mo Significant improvements in RP, mental component score, and RE of the SF-36 at 2 mo.
Farbu [2007] [12] VAS, muscle strength, and FSS at 1, 3, and 6 mo; TNF-α, IFN-γ, IL-6, IL-1β, IFN-β, and IL-10 levels in CSF and serum measured using enzyme-linked immunosorbent assay at 1 mo Significant alleviation of in pain at 3 mo; significantly decreased CSF TNF-α levels (P = 0.028; no significant differences after regression because of the differences in the baseline values).
Gonzalez [2006] [10] SF-36, VAS, MFI-20, PASE, 6MWT, TUG, muscle strength, balance, and sleep quality at 9–13 wk Significant improvements in the strength of the affected muscles and the vitality scores of the SF-36 and PASE.
Gonzalez [2012] [5] SF-36, 6MWT, and VAS; IFN-γ, TNF, IL-10, IL-13, IL-23, and TGF-β levels in PBMCs and CSF at 1 year Significant improvements in the physical components of the SF-36, VAS scores, and 6MWT. Significant decrease in the CSF IFN-γ and IL-23 levels but significant increase in the CSF IL-13 levels.
Gonzalez [2004] [13] IFN-γ, TNF-α, IL-10, and IL-4 levels in PBMCs and CSF at 6–8 wk Significant decrease in the CSF IFN-γ and TNF-α mRNA levels and significant increase in the PBMCs IL-4 levels.
Kaponides [2006] [8] SF-36 at 2 and 6 mo; 6MWT and muscle strength at 2 mo Significant improvements in the PF, RP, BP, GH, VT, SF, and MH subdomains of the SF-36 at 2 and 6 mo.
Östlund [2012] [11] SF-36, PASE, and VAS at 6 mo Significant improvement of pain in patients with VAS score > 2 cm, age < 65 y, and paresis of the lower limbs. Significant improvements in the BP, VT, SF, RE subdomains of the SF-36.
Werhagen[2011] [9] VAS at 6 mo 31/45 (69%) patients exhibited significant improvements in the mean VAS scores, which decreased from 53 to 42 (p = 0.001).
  1. 6MWT, 6-minute walk test; BP, bodily pain; CSF, cerebrospinal fluid; FSS, fatigue severity scale; GH, general health; IL, interleukin; IFN, interferon; MFI, multidimensional fatigue index; MH, mental health; PASE, physical activity scale for the elderly; PBMCs, peripheral blood mononuclear cells; PF, physical functioning; QoL, quality of life; RE, role emotional; RP, role physical; SF, social functioning; TGF: transforming growth factor; TNF, tumor necrosis factor; TUG, time up and go test; VAS, visual analog scale; and VT, vitality.