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Table 1 Assessment categories and instruments

From: Hypoxia and Outcome Prediction in Early-Stage Coma (Project HOPE): an observational prospective cohort study

Assessment category Instruments
Sociodemographic factors Age, gender, marital status, highest educational degree
Comorbidity Modified Cumulative Illness Rating Scale (mCIRS) [20, 21].
Severity of illness Simplified Acute Physiology Score (SAPS II) [22, 23].
Prognostication tests EEG, median-nerve somatosensory evoked potentials (SEP), NSE
Activities of daily living (ADL) Outcome Barthel index and the Barthel index for Early Rehabilitation (BI) [2326].
• Level of consciousness Coma recovery scale -revised (CRS-R) [11], Glasgow Coma Scale (GCS) [27], Full outline of unresponsiveness (FOUR) [28]
• Health status Neurological post-acute Core Set of the International Classification of Functioning, Disability and Health (ICF) [29]
• Cognitive functioning Since the most commonly observed cognitive impairments in patients with an anoxic-ischemic brain injury are disturbances of attention/processing speed, memory, and executive function we use the subtests of the Cologne Neuropsychological Screening for Stroke Patients (German: Koelner Neuropsychologisches Screening für Schlaganfall-Patienten) for these functions [30, 31].
• Psychosocial Outcome German version of the Hospital Anxiety and Depression Scale (HADS-D) [3234].
• Quality of life Short Form 36 (SF-36) Questionnaire (for patients as well as for closest care-providing relative) [35]
• Life Satisfaction (LS) and satisfaction with decision making at the ICU The LS of the patient and the closest care-providing person is measured by the “Question on Life Satisfaction (German: Fragen zur Lebenszufriedenheit-Module; FLZ-M) [36], and satisfaction with decision making at the ICU is measured with questions such as “in retrospective, I would have decided exactly the same on the ICU” using a 5-point scale.
• Overall outcome The modified Rankin scale (mRS) [37, 38], and the Cerebral Performance Category [39, 40]