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Table 1 Assessment categories and instruments

From: Hypoxia and Outcome Prediction in Early-Stage Coma (Project HOPE): an observational prospective cohort study

Assessment category

Instruments

Sociodemographic factors

Age, gender, marital status, highest educational degree

Comorbidity

Modified Cumulative Illness Rating Scale (mCIRS) [20, 21].

Severity of illness

Simplified Acute Physiology Score (SAPS II) [22, 23].

Prognostication tests

EEG, median-nerve somatosensory evoked potentials (SEP), NSE

Activities of daily living (ADL) Outcome

Barthel index and the Barthel index for Early Rehabilitation (BI) [2326].

• Level of consciousness

Coma recovery scale -revised (CRS-R) [11], Glasgow Coma Scale (GCS) [27], Full outline of unresponsiveness (FOUR) [28]

• Health status

Neurological post-acute Core Set of the International Classification of Functioning, Disability and Health (ICF) [29]

• Cognitive functioning

Since the most commonly observed cognitive impairments in patients with an anoxic-ischemic brain injury are disturbances of attention/processing speed, memory, and executive function we use the subtests of the Cologne Neuropsychological Screening for Stroke Patients (German: Koelner Neuropsychologisches Screening für Schlaganfall-Patienten) for these functions [30, 31].

• Psychosocial Outcome

German version of the Hospital Anxiety and Depression Scale (HADS-D) [3234].

• Quality of life

Short Form 36 (SF-36) Questionnaire (for patients as well as for closest care-providing relative) [35]

• Life Satisfaction (LS) and satisfaction with decision making at the ICU

The LS of the patient and the closest care-providing person is measured by the “Question on Life Satisfaction (German: Fragen zur Lebenszufriedenheit-Module; FLZ-M) [36], and satisfaction with decision making at the ICU is measured with questions such as “in retrospective, I would have decided exactly the same on the ICU” using a 5-point scale.

• Overall outcome

The modified Rankin scale (mRS) [37, 38], and the Cerebral Performance Category [39, 40]