Table 4 The Risk of Stroke Recurrence in association with Antidepressants in Subgroup of Other Drugs Use and Comorbidities
Adjusted HRa | (95 % CI) | |
|---|---|---|
Without antipsychotics | 1.40 | (1.18, 1.66) |
With antipsychotics | 1.45 | (1.16, 1.82) |
Without anticoagulant | 1.44 | (1.25, 1.65) |
With anticoagulant | 1.24 | (0.76, 2.00) |
Without antiplatelet | 1.41 | (1.23, 1.62) |
With antiplatelet | 1.52 | (0.72, 3.22) |
Without anti-inflammatory | 1.29 | (0.90, 1.85) |
With anti-inflammatory | 1.44 | (1.24, 1.67) |
Without anxiety or other mood disorders | 1.40 | (1.07, 1.82) |
With anxiety or other mood disorders | 1.42 | (1.21, 1.66) |
Without atrial fibrillation | 1.40 | (1.22, 1.62) |
With atrial fibrillation | 1.57 | (0.98, 2.50) |
Without coronary heart disease | 1.36 | (1.16, 1.60) |
With coronary heart disease | 1.59 | (1.24, 2.05) |
Without congestive heart failure | 1.44 | (1.25, 1.65) |
With congestive heart failure | 1.15 | (0.68, 1.97) |
Without chronic obstructive pulmonary disease | 1.49 | (1.29, 1.73) |
With chronic obstructive pulmonary disease | 1.09 | (0.77, 1.54) |
Without cancer | 1.42 | (1.24, 1.63) |
With cancer | 0.94 | (0.26, 3.32) |
Without diabetes mellitus | 1.20 | (0.99, 1.45) |
With diabetes mellitus+ | 1.70 | (1.41, 2.05) |
Without hypertension | 1.25 | (0.69, 2.27) |
With hypertension | 1.42 | (1.24, 1.64) |
Without hyperlipidemia | 1.41 | (1.18, 1.68) |
With hyperlipidemia | 1.42 | (1.15, 1.76) |
Antidepressants use before index date | ||
No--New Users | 1.57 | (1.32, 1.86) |
Yes--Prevalent Users | 1.23 | (0.99, 1.53) |
Depression at Baseline (index date) or Post-stroke | ||
No Depression | 1.55 | (1.32, 1.82) |
Depression at Baseline | 1.49 | (0.99, 2.26) |
Post-stroke Depression | 1.44 | (1.01, 2.07) |