Fig. 1

Top. Sagittal T1 MRI brain images of patient. Left: day 17, showing a large callosal haematoma. Bilateral subdural haematomas were also present as were post-surgical changes related to the previous ganglioglioma resection with ex-vacuo dilatation of the left temporal lobe. However there was no evidence of diffuse axonal injury and no evidence of cortical damage. Right: 12 months later, showing resolution of the haemorrhagic changes but marked atrophy of the body of the corpus callosum. MRI brain at 20 months showed no further changes (not shown). Bottom. Deterministic tracking of the callosal tract based on two regions of interest defining the corpus callosum on sagittal planes to the left and right of midline. The patient is above with a control below for comparison. The majority of interhemispheric direct connections (red) are lost except at the extremes of the genu and splenium