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Table 1 Treatment schedule weeks 1 to 80

From: Protocol of a randomised delayed-start double-blind placebo-controlled multi-centre trial for Levodopa in EArly Parkinson’s disease: the LEAP-study

   Early group Delayed group
Morning Noon Evening Morning Noon Evening
Phase 1 Week 1 (capsules) 50/12.5 Placebo 50/12.5 Placebo Placebo Placebo
Week 2 (capsules) 100/25 50/12.5 50/12.5 Placebo Placebo Placebo
Weeks 3 to 40 (tablets) 100/25 100/25 100/25 Placebo Placebo Placebo
Phase 2 Week 41 (capsules) 100/25 100/25 100/25 50/12.5 Placebo 50/12.5
Week 42 (capsules) 100/25 100/25 100/25 100/25 50/12.5 50/12.5
Week 43 to 80 (tablets) 100/25 100/25 100/25 100/25 100/25 100/25
  1. Doses are written as levodopa/carbidopa milligram