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Table 1 Demographics and risk factors in patients and probands
| Demographics | Total number | FD: R227Q | D313Y |
|---|---|---|---|
| Patients | 178 | 1 | 1 |
| Men | 73 (40,7 %) | 1 | 0 |
| Age at recruitment | 48,4a | 41 | 52 |
| Age at onset (symptomatic) | 43,3a | 48 | |
| Age at onset (WMLs) | 43,5a | 41 | |
| Risk factors | |||
| Hypertension | 106 (59,5 %) | 1 | 1 |
| Diabetes | 11 (6,1 %) | 0 | 0 |
| Atrial fibrillation | 3 (1,7 %) | 0 | 0 |
| Dyslipidemia | 83 (46,6 %) | 0 | 1 |
| Smoking | 40 (22,4 %) | 0 | 0 |
| Drinking habit | 13 (7,3 %) | 0 | 0 |
| Oral contraception | 5 (4,7 %) | NA | 0 |
| Hyperhomocysteine | 22 (12,3 %) | 1 | 1 |
| Overweight/obesity | 68 (38,2 %) | 0 | 1 |
| Fabry feature | |||
| Acroparesthesia | 13 (7,3 %) | 1 | 0 |
| Angiokeratoma | 0 | 0 | 0 |
| Cornea verticillata | 1 (0,5 %) | 0 | 0 |
| CKD/Proteinuria | 22 (12,3 %) | 0 | 1 |
| Cardiac involvement | 32 (17,97 %) | 1 | 1 |
