Weight^{a} [g]

Baseline (Before)

358 [343–383]

343 [334–367]

345 [326–372]

p = 0.375

400 [375–413]

Day 1

342 [328–367]

335 [314–361]

339 [322–360]
 
384 [360–409]

Wilcoxon Test p

0.01

<0.01

0.02
 
0.04

Day 2

338 [322–354]

323 [306–351]

323 [304–345]
 
389 [365–404]

Day 3

342 [327–362]

327 [306–355]

330 [308–343]
 
391 [361–408]

Day 4

339 [327–372]

329 [309–365]

328 [313–345]
 
400 [369–410]

Day 5

348 [324–380]

341 [319–370]

332 [318–355]
 
401 [374–415]

FriedmanTest p

<0.001
^{a}

<0.001
^{a}

<0.001
^{a}
 
<0.001
^{a}

Linear regression with clustered robust SE p = 0.302

(Coef. helium: −11.9 CI −33.0 to 9.2; Coef. argon: −15.2 CI −36.1 to 5.6)

Time effect: fractional polynomial regression p = 0.001

Tape Removal Test^{a} [seconds]

Baseline (Before)

18 [11–29]

9 [5–12]

13 [8–23]

p = 0.06

17 [14–39]

Day 1

74 [21–120]

120 [35–120]

85 [23–120]
 
10 [8–21]

Wilcoxon Test p

0.01

<0.01

<0.01
 
0.38

Day 2

21 [12–76]

18 [11–111]

17 [9–120]
 
14 [7–18]

Day 3

20 [8–113]

16 [11–120]

31 [9–88]
 
18 [15–95]

Day 4

14 [10–113]

11 [7–59]

17 [9–120]
 
19 [7–96]

Day 5

12 [7–45]

9 [5–44]

11 [7–93]
 
12 [7–17]

FriedmanTest p

0.018
^{a}

0.002
^{a}

0.023
^{a}
 
0.086

Linear regression with clustered robust SE p = 0.980

(Coef. helium: −2.01 CI −35.88 to 31.86; Coef. argon: −3.24 CI −36.49 to 30.01)

Time effect: fractional polynomial regression p < 0.001

Neuro Deficit Score^{a} [range: 0–100]

Baseline (Before)

0 [0–0]

0 [0–0]

0 [0–0]

p = 0.37

0 [0–0]

Day 1

2.5 [0–3.0]

3.0 [0.5–3.0]

2.5 [0.5–3.0]
 
0 [0–0]

Wilcoxon Test p

0.02

0.02

0.03
 
1.0

Day 2

0 [0–2.3]

0 [0–2.0]

0 [0–1.5]
 
0 [0–0]

Day 3

0 [0–0.3]

0 [0–1.3]

0 [0–0.5]
 
0 [0–0]

Day 4

0 [0–0.3]

0 [0–0.5]

0 [0–0]
 
0 [0–0]

Day 5

0 [0–0.3]

0 [0–0.3]

0 [0–0]
 
0 [0–0]

FriedmanTest p

<0.001^{a}

<0.001^{a}

<0.001^{a}
 
1.0

Linear regression with clustered robust SE p = 0.612

(Coef. helium: 0.50 CI −0.68 to 1.69; Coef. argon: 0.35 CI −0.63 to 1.32)

Time effect: fractional polynomial regression p < 0.001

Vertical Pole Test^{a} [range: 0–3]

Baseline (Before)

0 [0–0]

0 [0–0]

0 [0–0]

p = 0.60

0 [0–0]

Day 1

2.5 [0.25–3.0]

3.0 [1.0–3.0]

2.5 [1.5–3.0]
 
0 [0–0]

Wilcoxon Test p

0.03

0.02

0.03
 
1.0

Day 2

0 [0–2.0]

0 [0–1.5]

0 [0–1.0]
 
0 [0–0]

Day 3

0 [0–0]

0 [0–1.0]

0 [0–0]
 
0 [0–0]

Day 4

0 [0–0]

0 [0–0]

0 [0–0]
 
0 [0–0]

Day 5

0 [0–0]

0 [0–0]

0 [0–0]
 
0 [0–0]

FriedmanTest p

<0.001^{a}

<0.001^{a}

<0.001^{a}
 
1.0

Linear regression with clustered robust SE p = 0.663

(Coef. helium: 0.15 CI −0.34 to 0.64; Coef. argon: 0.21 CI −0.32 to 0.75)

Time effect: fractional polynomial regression p < 0.001

Open Field Test: distance^{a} [cm]

Baseline (Before)

1691 [1327–1900]

1769 [1620–2101]

1580 [1520–1951]

p = 0.23

1693 [1378–1938]

Day 4

1673 [1161–1919]

1320 [1144–1712]

2058 [1698–2403]
 
1034 [799–1698]

Day 5

851 [758–1343]

1240 [658–1606]

962 [711–1629]
 
774 [698–1196]

FriedmanTest p

0.06

0.07

0.24
 
0.02^{a}

Linear regression with clustered robust SE p = 0.156

(Coef. helium: −244 CI −528 to 39; Coef. argon: −5 CI −465 to 455)

Time effect: fractional polynomial regression p = 0.002

Open Field Test: mobility/immobility ratio^{a} [%]

Baseline (Before)

82 [77–88]

88 [81–92]

84 [82–87]

p = 0.24

83 [80–85]

Day 4

81 [71–84]

81 [75–88]

85 [82–87]
 
65 [54–84]

Day 5

59 [51–72]

77 [50–86]

67 [46–82]
 
56 [41–65]

FriedmanTest p

0.15

0.20

0.06
 
<0.01
^{a}

Linear regression with clustered robust SE p = 0.112

(Coef. helium: −4.63 CI −11.87 to 2.62; Coef. argon: 2.51 CI −6.22 to 11.24)

Time effect: fractional polynomial regression p < 0.001

Open Field Test: extern/intern ratio^{a} [%]

Baseline (Before)

94 [93–96]

94 [93–96]

96 [94–97]

p = 0.84

96 [93–98]

Day 4

99 [97–100]

98 [96–99]

95 [95–97]
 
100 [97–100]

Day 5

100 [99–100]

99 [99–100]

99 [95–100]
 
100 [98–100]

FriedmanTest p

0.02
^{a}

0.03
^{a}

0.03
^{a}
 
0.03
^{a}

Linear regression with clustered robust SE p = 0.501

(Coef. helium: 0.68 CI −1074 to 2.10; Coef. argon: 0.33 CI −1.55 to 2.22)

Time effect: fractional polynomial regression p = 0.003

Open Field Test: rears/vertical^{a} [count]

Baseline (Before)

15 [12–23]

20 [19–23]

19 [16–22]

p = 0.21

17 [14–22]

Day 4

6 [5–8]

5 [3–10]

8 [5–9]
 
9 [7–13]

Day 5

3 [1–4]

6 [2–9]

4 [2–7]
 
7 [4–9]

FriedmanTest p

<0.001
^{a}

<0.001
^{a}

<0.001
^{a}
 
<0.001
^{a}

Linear regression with clustered robust SE p = 0.107

(Coef. helium: −2.73 CI −5.58 to 0.11; Coef. argon: −0.40 CI −4.13 to 3.33)

Time effect: fractional polynomial regression p < 0.001
