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Table 1 Clinical data of patients with RESLES associated with encephalitis/encephalopathy

From: Reversible splenial lesion syndrome associated with encephalitis/encephalopathy presenting with great clinical heterogeneity

patient no.

age/sex

initial symptom

CNS manifestation (onset day)

CNS diagnosis

EEG

CSF

pathogens

therapy

prognosis (day)

1

15/M

fever

headache (2d)

encephalopathy

slow BA

normal

negative

None

CR (14d)

2

23/M

fever, nasal congestion, pharyngalgia

headache, seizure, disturbance of consciousness, meningeal irritation sign (6d)

meningoencephalitis

NE

CC: 20

influenza A

MPSL, IVIG, ACV, MV, CBZ, antibiotics,

vegetative state

3

27/F

fever, cough

headache, ataxia, slurred language (2d)

encephalopathy

NE

normal

negative

Dex, ACV

CR (9d)

4

38/M

fever, nasal congestion, cough

headache, vertigo (1d)

encephalopathy

NE

normal

herpesvirus-6

ACV

CR (11d)

5

26/M

fever, myalgias

headache, disturbance of consciousness (2d)

encephalitis

slow BA

CC:110

negative

ACV, Dex, antibiotics

CR (10d)

6

31/M

fever, pharyngalgia

vertigo (3d)

encephalopathy

slow BA

normal

negative

ACV, antibiotics

CR (20d)

7

16/M

fever, cough

headache, delirious behavior, disturbance of consciousness (2d)

encephalitis

NE

CC: 15

negative

MPSL, IVIG, ACV, MV,

agrypnocoma

8

37/F

fever, myalgias

headache, tremor (1d)

encephalopathy

normal

normal

negative

None

CR (25d)

9

25/F

fever, cough, pharyngalgia

headache, vertigo (3d)

encephalopathy

NE

normal

influenza B

ACV

CR(7d)

10

30/M

fever

limb numbness, slurred language (2d)

encephalopathy

normal

normal

negative

None

CR(12d)

11

30/F

fever, nasal congestion

headache, delirious behavior (5d)

encephalitis

normal

normal

EB virus

ACV, Dex

CR (7d)

12

13/M

fever

headache, disturbance of consciousness, seizure, meningeal irritation sign (1d)

meningoencephalolitis

slow BA

CC: 73

negative

ACV, PB, IVIG, antibiotics

CR (6d)

13

33/F

none

vertigo

encephalopathy

normal

normal

negative

None

CR (14d)

14

25/F

cough, pharyngalgia

headache (3d)

encephalopathy

NE

NE

negative

ACV

CR (10d)

15

15/M

fever

headache (1d)

encephalitis

normal

CC: 19

negative

ACV, Dex

CR (15d)

  1. CNS central nervous system, EEG electroencephalogram, CSF cerebrospinal fluid, BA basic activity, CR complete recovery, NE not examined, CC cell counting (cells/uL), MPSL methylprednisolone, IVIG intravenous immunoglobulin, ACV acyclovir, MV mechanical ventilation, CBZ carbamazepine, SL slurred language, Dex dexamethasone, PB phenobarbital