Fig. 1
From: Novel PSEN1 G209A mutation in early-onset Alzheimer dementia supported by structural prediction
a Axial and coronal FLAIR images of brain MRI. The upper images at the age of 48 show that bilateral parietal atrophy (empty arrow). The lowers at the age of 54 show that diffuse cortical atrophy and prominent atrophic change in medial temporal (arrow head) and bilateral parietal lobes (filled arrow). b Statistical parametric maps (11 age matched control subjects; p < 0.001, uncorrected; extent threshold = 50 voxels) of FDG-PET of the patient, which reveal the bilateral temporal, parietal, precuneal and frontal hypometabolism. The color scale of statistical parametric maps indicates the Z value magnitude, with the lowest value appearing in dark red and the highest value in bright yellow/white