Table 4 Usual suspects? Top 10 causes of serotonin syndrome
From: Conundrums in neurology: diagnosing serotonin syndrome – a meta-analysis of cases
Cause | All cases (n = 299) | Accounting for ICU cases (n = 114) |
|---|---|---|
% | % | |
Combination antidepressant - opiate | 16.1 | 10.5 |
Overdose | 15.4 | 26.3 |
Combination antidepressant with another potentially serotonergic agenta | 13.0 | 7.9 |
Combination of different antidepressants | 7.7 | 5.3 |
Combination antidepressant - linezolid | 7.0 | 9.6 |
Swap antidepressants | 6.4 | 4.4 |
Combination antidepressant – methylene blue | 5.4 | 11.4 |
Start of antidepressants | 4.7 | - |
Substance misuse | 4.3 | 8.8 |
Start/ discontinuation of second generation antipsychotics in the presence of another pro-serotonergic agenta | 3.3 | 2.6 |