Fig. 3
From: Hyperekplexia, microcephaly and simplified gyral pattern caused by novel ASNS mutations, case report
Brain MR images at day 1 after birth of patient 1. a Sagittal T1-weighted image showing severe microcephaly, simplified gyral pattern, thin corpus callosum, small cerebellum, and small pons. b Axial T1-weighted image demonstrating small pons and cerebellum. c Axial T1-weighted image showing delayed myelination of the posterior limb of internal capsule, bilaterally. d Coronal FLAIR image demonstrating severely simplified gyral pattern and large extra-axial CSF spaces reflecting brain underdevelopment. e Proton MR Spectroscopy with long TE showing normal spectra for age