Mean (median) annualized percentage brain volume change (PBVC). Results from the SELECT placebo group have been published previously . The annualized PBVC was determined with Structural Image Evaluation using Normalization of Atrophy (SIENA) and was calculated as percentage change divided by the number of days since the last scan multiplied by 365.25. For PBVC endpoints, patients with any post-baseline magnetic resonance imaging assessment in the efficacy population were included in the analysis. *Gold et al.