Fig. 4

Patient evaluation in PANGAEA 2.0. The software-based MS management system MSDS 3D is supporting patient management (1) and assists physicians in executing all evaluations required for MS diagnosis, treatment initiation, assess safety, and long-term treatment outcome. Patient status (2) is evaluated by means of the 2D Focused Disability Scale (2D FDS) that comprises clinical and subclinical measures representing both the patient’s and the physician’s perspectives (UKNDS: United Kingdom Neurological Disability Scale; FSMC: Fatigue Scale for Motor Fatigue and Cognitive Functions; WPAI-MS: Work Productivity and Activities Impairment; EQ-5D: EuroQuol-5D; EDSS: Expanded Disability Status Scale; SDMT: Symbol Digit Modality Test; CGI: Clinical Global Impression). Standardized quantitative evaluation of routine MRI scans (3) is performed by a central reading facility. The MRI protocol for MRI acquisition and the parameters for quantitative MRI evaluation of lesion load, lesion volume and brain volume are shown. Propose patient evaluation in PANGAEA 2.0