Table 3 Disease characteristics
Disease characteristics | Everolimus N  =  120 |
|---|---|
Time since TSC diagnosis, median (range), years | 9.1 (0.2–30.7) |
Time since SEGA diagnosis, median (range), years | 3.8 (0–24) |
Modified Gomez criteria - major features, n (%) | |
 Facial angiofibromas or forehead plaques | 93 (77.5) |
 Non-traumatic ungual or periungual fibroma | 18 (15.0) |
 Hypomelanotic macules (3 or more) | 95 (79.2) |
 Shagreen patch (connective tissue nevus) | 47 (39.2) |
 Multiple retinal nodular hamartomas | 23 (19.2) |
 Cortical tuber | 106 (88.3) |
 Subependymal nodule | 102 (85.0) |
 Subependymal giant cell astrocytoma | 120 (100.0) |
 Cardiac rhabdomyoma, single or multiple | 55 (45.8) |
 Lymphangioleiomyomatosis | 2 (1.7) |
 Renal angiomyolipoma | 59 (49.2) |
Modified Gomez criteria - minor features, n (%) | |
 Multiple, randomly distributed pits in dental enamel | 6 (5.0) |
 Hamartomatous rectal polyps | 0 (0.0) |
 Bone cysts | 2 (1.7) |
 Cerebral white matter radial migration lines | 16 (13.3) |
 Gingival fibromas | 6 (5.0) |
 Non-renal hamartoma | 3 (2.5) |
 Retinal achromic patch | 4 (3.3) |
 'Confetti' skin lesions | 15 (12.5) |
 Multiple renal cysts | 19 (15.8) |