| Â | Weight (g) before MCAo | Weigth (g) before CBF | MABP (mmHg) | Heart rate (n/min) | pH | pCO2 (mmHg) | pO2 (mmHg) |
|---|
WT | 43.2 ± 1.7 | 41.9 ± 1.6 | 94 ± 1.7 | 366 ± 10 | 7.28 ± 0.02 | 42.7 ± 0.7 | 94.8 ± 2.0 |
VEC+/- | 41.6 ± 0.9 | 38.8 ± 0.6 | 100.3 ± 2.3 | 391 ± 7.8 | 7.29 ± 0.01 | 44.1 ± 0.7 | 95.6 ± 1.3 |
- Summary of physiological data obtained during CBF measurements. Weight (g) before MCAo: Body weights of all mice entered into the CBF experiments (10 VEC+/+ and 16 VEC+/-). Weight (g) before CBF: Body weights of all mice which had survived up to this point (N = 8 VEC+/+ and 11 VEC+/- mice). MABP (mmHg), heart rate (n/min), pH, pCO2 (mmHg), and pO2 (mmHg) were also assessed in 8 VEC+/+ mice and 11 VEC+/- mice. Please note that, following physiological measurements, one VEC+/+ mouse died during preparation for blood flow experiments. Moreover, due to technical issues with the femoral artery catheter, one VEC+/+ and one VEC+/- animal each could not be used for measurement of CBF (see legend to Fig. 4)
