Skip to main content

Table 1 Characteristics of included studies

From: Efficacy and safety of pharmacological treatments for Lyme neuroborreliosis in children: a systematic review

Study Sample size Case definition Interventions Length of treatment Setting Country
RCT
 Millner 1995 41 possible penicillin G 300,000-375,000 IU/kg, ceftriaxone 100 mg/kg, sample size of groups not reported 14 days Tertiary care center Austria
 Müllegger 1991 23 possible penicillin G 400,000-500,000 IU/kg (n = 11), ceftriaxone 75–93 mg/kg (n = 12) 14 days Tertiary care center Austria
Prospective cohort studies
 Jörbeck 1987 9 possible penicillin G 150 mg/kg (n = 8), cefuroxime 4.5 g (n = 1) 10–19 days Tertiary care center Sweden
Retrospective cohort studies   
 Thorstrand 2002 203 probable ceftriaxone 100 mg/kg, maximum 2 g (n = 109), penicillin 100 mg/kg (n = 53), doxycycline 4 mg/kg, maximum 200 mg (n = 22), cefotaxime 100 mg/kg (n = 19) 10 days Tertiary care center Sweden
 Bingham 1995 19 possible ceftriaxone, amoxicillin, erythromycin, penicillin, doxycycline, steroids, aciclovir or no treatment. Dosages not stated. 14–30 days Tertiary care center USA
 Skowronek-Bala 2008 9 possible ceftazidim + doxycycline (n = 5), amoxicillin + doxycycline (n = 1), ceftazidim + amoxicillin (n = 1), doxycycline (n = 1), ceftazidim (n = 1) 3–6 weeks Tertiary care center Poland