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Table 5 Second- and third-degree AV blocks during treatment initiation

From: Electrocardiographic assessments and cardiac events after fingolimod first dose – a comprehensive monitoring study

  Fingolimod 0.5 mg N = 3951
Patients with 12-lead ECG recording, n N = 3951
 Patients with first-degree AV block, n (%) 280 (7.1)
 Pre-dose 96 (2.7)
 Post-dose 206 (5.8)
Patients with Holter ECG recording, n N = 3906
 Patients with second-degree AV block, n (%) 62 (1.6)
 Mobitz Type I (Wenckebach) 60 (1.5)a
 2:1 18 (0.5)a
 Mobitz Type II (Mobitz) 0
 Patients with third-degree AV block, n (%) 0
  1. aA patient might experience both Mobitz type I and 2:1 AV blocks during the six-hour monitoring