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Table 1 Characteristics of reviewed studies reporting associations between polymorphisms and AEDs resistance epilepsy

From: Relationship between ABCB1 3435TT genotype and antiepileptic drugs resistance in Epilepsy: updated systematic review and meta-analysis

Gene Polymorphism Genotype model Ethnicity Reference
ABCB1 c.1199G > A
(rs2229109)
GA vs. GG Mexican Escalante-Santiago et al. 2014 [71]
c.1236T > C
(rs1128503)
CC + CT vs. TT Iranian Maleki et al. 2010 [72]
c.2677G > T/A
(rs2032582)
AT + AG vs. GG + GT + TT Mexican Escalante-Santiago et al. 2014 [71]
TT vs. GG + GT European Sánchez et al. 2010 [31]
Malaysian Subenthiran et al. 2013 [37]
TT vs. GG Subenthiran et al. 2013 [73]
Japanese Seo et al. 2006 [36]
c.3435C > T
(rs1045642)
CC vs. TT Chinese Hung et al. 2005 [22]
Hung et al. 2007 [23]
Egyptian Ebid et al. 2007 [24]
European Sánchez et al. 2010 [31]
Siddiqui et al. 2003 [25]
  Stasiołek et al. 2016 [26]
Indian Taur et al. 2014 [27]
Iranian Sayyah et al. 2011 [28]
  Thai Keangpraphun et al. 2015 [29]
CC vs. CT + TT European Basic et al. 2008 [30]
Sánchez et al. 2010 [31]
CC + CT vs. TT Soranzo et al. 2004 [32]
CT vs. CC + TT Iranian Sayyah et al. 2011 [28]
TT vs. CC Australian Tan et al. 2004 [33]
Chinese Kwan et al. 2007 [34]
Indian Shaheen et al. 2014 [35]
Japanese Seo et al. 2006 [36]
TT vs. CT + CC Malaysian Subenthiran et al. 2013 [37]
ABCC2 c.-24C > T (rs717620) CT + TT vs. CC Chinese Qu et al. 2012 [74]
c.-1019A > G
(rs2804402)
AA vs. AG + GG Indian Grover et al. 2012 [75]
c.-1549G > A
(rs1885301)
GG vs. GA + AA
c.1249G > A
(rs2273697)
AA vs. GG Malaysian Sha’ari et al. 2014 [50]
Japanese
Chinese
GA vs. GG
GA + AA vs. GG
GA vs. GG + AA Ma et al. 2014 [51]
c.3972C > T (rs3740066) CT vs. CC
CC + TT vs. CC
Malaysian Sha’ari et al. 2014 [50]
Chinese
CT + TT vs. CC Qu et al. 2012 [74]
TT vs. CC + CT Mexican Escalante-Santiago et al. 2014 [71]
ApoE c.388T > C
(rs429358),
c.526C > T
(rs7412)
e3/4 vs. e3/3 + e2/3 European Sporiš et al. 2005 [76]
c.388T > C
(rs429358)
e4 vs. e2 + e3 Chinese Gong et al. 2016 [77]
CYP1A1 IVS1 + 606C > A
(rs2606345)
CC + CA vs. AA
CC vs. CA + AA
Indian Grover et al. 2010 [78]
CYP2C9 c.1075A > C
(rs1057910)
CYP2C9*3/*3 vs. CYP2C9*1/*1+
CYP2C9*1/*3
European Seven et al. 2014 [79]
GABRA1 IVS11 + 15A > G
(rs2279020)
GG vs. AA + AG Indian Kumari et al. 2010 [80]
Kumari et al. 2011 [81]
c.74 + 448C > T (rs6883877) CC vs. TC + TT Thai Hung et al. 2013 [82]
GABRA2 g.46240004A > G
(rs511310)
GG vs. AA + AG
GABRA3 c.-27 + 37622A > G
(rs4828696)
TT vs. CC + CT
GAT3 c.1572C > T
(rs2272400)
CT + TT vs. CC Korean Kim et al. 2011 [83]
GSTM1 GSTM1*0 GSTM1- vs. GSTM1+ Chinese Liu et al. 2002 [84]
SCN1A c.3184A > G
(rs2298771)
AA vs. AG + GG Wang et al. 2014 [85]
AG + GG vs. AA Zhou et al. 2012 [86]
AG vs. AA + GG Egyptian Abo El Fotoh et al. 2016 [87]
IVS5-91G > A
(rs3812718)
AA vs. AG + GG Japanese Ma et al. 2014 [51]
Abe et al. 2008 [62]
SCN2A IVS7-32A > G
(rs2304016)
AA vs. AG + GG Chinese Kwan et al. 2008 [88]
SLC6A4 5-HTTLPR L/L vs. S/L + S/S European Hecimovic et al. 2010 [89]
STin2 VNTR 12/12 vs. 10/10 Argentinean Kauffman et al. 2009 [90]
12/12 vs. 10/12 + 10/10 European Hecimovic et al. 2010 [89]
  1. Abbreviation: ABCB1 atp-binding cassette sub-family b member 1, ABCC2 atp-binding cassette subfamily c member 2, ApoE apolipoprotein e, CYP1A1 cytochrome p450 1a1, CYP2C9 cytochrome p450 family member 2c9, GABRA1 gamma-aminobutyric acid-a receptor alpha1-subunit, GABRA2 gamma-aminobutyric acid-a receptor alpha2-subunit, GABRA3 gamma-aminobutyric acid-a receptor alpha3-subunit, GAT3 gamma-aminobutyric acid transporter 3, GSTM1 glutathione s-transferases mu 1, SCN1A sodium channel nav1.1, SCN2A sodium channel nav1.2, SLC6A4 solute ligand carrier family 6 member a4