Table 1 Characteristics of reviewed studies reporting associations between polymorphisms and AEDs resistance epilepsy
Gene | Polymorphism | Genotype model | Ethnicity | Reference |
|---|---|---|---|---|
ABCB1 | c.1199G > A (rs2229109) | GA vs. GG | Mexican | Escalante-Santiago et al. 2014 [71] |
c.1236T > C (rs1128503) | CC + CT vs. TT | Iranian | Maleki et al. 2010 [72] | |
c.2677G > T/A (rs2032582) | AT + AG vs. GG + GT + TT | Mexican | Escalante-Santiago et al. 2014 [71] | |
TT vs. GG + GT | European | Sánchez et al. 2010 [31] | ||
Malaysian | Subenthiran et al. 2013 [37] | |||
TT vs. GG | Subenthiran et al. 2013 [73] | |||
Japanese | Seo et al. 2006 [36] | |||
c.3435C > T (rs1045642) | CC vs. TT | Chinese | Hung et al. 2005 [22] | |
Hung et al. 2007 [23] | ||||
Egyptian | Ebid et al. 2007 [24] | |||
European | Sánchez et al. 2010 [31] | |||
Siddiqui et al. 2003 [25] | ||||
|  | Stasiołek et al. 2016 [26] | |||
Indian | Taur et al. 2014 [27] | |||
Iranian | Sayyah et al. 2011 [28] | |||
| Â | Thai | Keangpraphun et al. 2015 [29] | ||
CC vs. CT + TT | European | Basic et al. 2008 [30] | ||
Sánchez et al. 2010 [31] | ||||
CC + CT vs. TT | Soranzo et al. 2004 [32] | |||
CT vs. CC + TT | Iranian | Sayyah et al. 2011 [28] | ||
TT vs. CC | Australian | Tan et al. 2004 [33] | ||
Chinese | Kwan et al. 2007 [34] | |||
Indian | Shaheen et al. 2014 [35] | |||
Japanese | Seo et al. 2006 [36] | |||
TT vs. CT + CC | Malaysian | Subenthiran et al. 2013 [37] | ||
ABCC2 | c.-24C > T (rs717620) | CT + TT vs. CC | Chinese | Qu et al. 2012 [74] |
c.-1019A > G (rs2804402) | AA vs. AG + GG | Indian | Grover et al. 2012 [75] | |
c.-1549G > A (rs1885301) | GG vs. GA + AA | |||
c.1249G > A (rs2273697) | AA vs. GG | Malaysian | Sha’ari et al. 2014 [50] | |
Japanese | ||||
Chinese | ||||
GA vs. GG | ||||
GA + AA vs. GG | ||||
GA vs. GG + AA | Ma et al. 2014 [51] | |||
c.3972C > T (rs3740066) | CT vs. CC CC + TT vs. CC | Malaysian | Sha’ari et al. 2014 [50] | |
Chinese | ||||
CT + TT vs. CC | Qu et al. 2012 [74] | |||
TT vs. CC + CT | Mexican | Escalante-Santiago et al. 2014 [71] | ||
ApoE | c.388T > C (rs429358), c.526C > T (rs7412) | e3/4 vs. e3/3 + e2/3 | European | Sporiš et al. 2005 [76] |
c.388T > C (rs429358) | e4 vs. e2 + e3 | Chinese | Gong et al. 2016 [77] | |
CYP1A1 | IVS1 + 606C > A (rs2606345) | CC + CA vs. AA CC vs. CA + AA | Indian | Grover et al. 2010 [78] |
CYP2C9 | c.1075A > C (rs1057910) | CYP2C9*3/*3 vs. CYP2C9*1/*1+ CYP2C9*1/*3 | European | Seven et al. 2014 [79] |
GABRA1 | IVS11 + 15A > G (rs2279020) | GG vs. AA + AG | Indian | Kumari et al. 2010 [80] |
Kumari et al. 2011 [81] | ||||
c.74 + 448C > T (rs6883877) | CC vs. TC + TT | Thai | Hung et al. 2013 [82] | |
GABRA2 | g.46240004A > G (rs511310) | GG vs. AA + AG | ||
GABRA3 | c.-27 + 37622A > G (rs4828696) | TT vs. CC + CT | ||
GAT3 | c.1572C > T (rs2272400) | CT + TT vs. CC | Korean | Kim et al. 2011 [83] |
GSTM1 | GSTM1*0 | GSTM1- vs. GSTM1+ | Chinese | Liu et al. 2002 [84] |
SCN1A | c.3184A > G (rs2298771) | AA vs. AG + GG | Wang et al. 2014 [85] | |
AG + GG vs. AA | Zhou et al. 2012 [86] | |||
AG vs. AA + GG | Egyptian | Abo El Fotoh et al. 2016 [87] | ||
IVS5-91G > A (rs3812718) | AA vs. AG + GG | Japanese | Ma et al. 2014 [51] | |
Abe et al. 2008 [62] | ||||
SCN2A | IVS7-32A > G (rs2304016) | AA vs. AG + GG | Chinese | Kwan et al. 2008 [88] |
SLC6A4 | 5-HTTLPR | L/L vs. S/L + S/S | European | Hecimovic et al. 2010 [89] |
STin2 VNTR | 12/12 vs. 10/10 | Argentinean | Kauffman et al. 2009 [90] | |
12/12 vs. 10/12 + 10/10 | European | Hecimovic et al. 2010 [89] |