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Table 3 NPRS ‘average pain’ scores at baseline and Weeks 2 and 8 (FAS)

From: Effectiveness of the capsaicin 8% patch in the management of peripheral neuropathic pain in European clinical practice: the ASCEND study

NPRS ‘average pain’ scores PHN
(n = 89)
HIV-AN
(n = 5)
NBP
(n = 50)
CRNP
(n = 22)
PONP
(n = 198)
Other
(n = 56)
Overall
(n = 420)
First treatment
 Baseline, mean (95% CI) 7.1 (6.9, 7.5)
n = 88
6.4 (5.1, 7.7)
n = 5
7.3 (6.8, 7.9)
n = 50
7.2 (6.6, 7.8)
n = 22
6.8 (6.6, 7.1)
n = 198
6.9 (6.4, 7.4)
n = 56
6.9 (6.7, 7.1)
n = 419
 Weeks 2 and 8, mean (95% CI) 4.9 (4.4, 5.4)
n = 89
4.6 (2.0, 7.3)
n = 4
4.8 (4.2, 5.5)
n = 48
5.8 (4.9, 6.7)
n = 21
5.2 (4.9, 5.5)
n = 195
4.5 (4.0, 5.1)
n = 56
5.0 (4.8, 5.2)
n = 412
 Percentage reduction, mean (95% CI) 29.7 (23.4, 36.0) 34.5 (7.6, 61.5) 30.9 (21.7, 40.1) 21.0 (11.6, 30.5) 22.3 (17.7, 27.0) 34.3 (27.3, 41.4) 26.6 (23.6, 29.6)
Second treatment
 Baseline, mean (95% CI) 7.1 (6.5, 7.7)
n = 39
6.5 (3.6, 9.4)
n = 2
7.7 (6.7, 8.7)
n = 15
6.9 (5.9, 7.9)
n = 8
6.8 (6.4, 7.2)
n = 97
6.6 (5.7, 7.5)
n = 19
6.9 (6.6, 7.2)
n = 180
 Weeks 2 and 12, mean (95% CI) 4.7 (4.1, 5.3)
n = 39
3 (–)
n = 2
4.3 (2.8, 5.8)
n = 12
3.4 (1.6, 5.2)
n = 6
4.9 (4.4, 5.4)
n = 85
5.1 (4.1, 6.1)
n = 18
4.8 (4.5, 5.1)
n = 162
 Percentage reduction, mean (95% CI) 30.5 (19.8, 41.2)
n = 38
51.3 (29.2, 73.4)
n = 2
44.9 (24.7, 65.1)
n = 12
51.0 (24.3, 77.7)
n = 6
25.0 (16.5, 33.5)
n = 85
21.4 (5.2, 37.6)
n = 18
28.7 (22.9, 34.5)
n = 161
Third treatment
 Baseline, mean (95% CI) 6.9 (5.9, 7.9)
n = 16
7.5 (4.6, 10.4)
n = 4
7.8 (6.3, 9.3)
n = 4
6.3 (5.8, 6.8)
n = 38
6.8 (5.6, 8.0)
n = 8
6.7 (6.3, 7.1)
n = 70
 Weeks 2 and 12, mean (95% CI) 3.9 (2.9, 4.9)
n = 14
5.5 (3.5, 7.5)
n = 4
5.0 (2.6, 7.4)
n = 4
4.4 (3.7, 5.1)
n = 29
5.2 (4.2, 6.2)
n = 8
4.5 (4.0, 5.0)
n = 59
 Percentage reduction, mean (95% CI) 42.3 (26.8, 57.8)
n = 14
25.4 (15.3, 35.5)
n = 4
35.5 (8.8, 62.2)
n = 4
23.1 (9.5, 36.7)
n = 29
13.6 (–20.8, 48.0)
n = 8
27.3 (18.1, 36.5)
n = 59
  1. CI, confidence interval; CRNP, cancer-related neuropathic pain; FAS, full analysis set; HIV-AN, HIV associated neuropathy; NBP, neuropathic back pain; NPRS, numeric pain rating scale; Other, other non-diabetic PNP; PHN, postherpetic neuralgia; PONP, post-operative and post-traumatic neuropathic pain