A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls

Table 3 Relationship between the clinical information of the FIQR and the components of the FMS biosignature

Bivariate components for the correlation analysis	Pearson correlation		Spearman correlation
Bivariate components for the correlation analysis	Coeff. (r)	p-value^b	Coeff. (r)	p-value
Correlations of the biosignature (SUM-3)^a with the FIQR domain categories
SUM-3 vs Sum of 21 questions of the full FIQR	0.35	0.102	0.42	0.059
SUM-3 vs Sum of 9 questions of the functional domain	0.31	0.134	0.25	0.134
SUM-3 vs Sum of 2 questions of the impact domain	0.15	0.316	0.22	0.241
SUM-3 vs Sum of 10 questions of the symptoms domain	0.41	0.057	0.57	0.011*
Correlations of two components of the biosignature (SUM-2) with the FIQR domain categories
SUM-2 vs Sum of 21 questions of the full FIQR	0.56	0.016*	0.53	0.021*
SUM-2 vsSum of 9 questions of the functional domain	0.52	0.023*	0.41	0.008**
SUM-2 vs Sum of 2 questions of the impact domain	0.5	0.043*	0.51	0.039*
SUM-2 vs Sum of 10 questions of the symptoms domain	0.59	0.009**	0.57	0.011*
Correlations of components of the biosignature with the symptom of pain^c
SUM-3 vs pain experience	0.46	0.037*	0.64	0.004**
SUM-2 vs pain experience	0.52	0.02*	0.54	0.016*
Creatine vs pain experience	0.5	0.025*	0.5	0.024*
Succinic acid vs pain experience	0.08	0.384	0.18	0.249
Taurine vs pain experience	0.39	0.069	0.29	0.135
Correlations of components of the biosignature with the symptom of energy^d
SUM-3 vs energy loss	0.32	0.115	0.61	0.006**
SUM-2 vs energy loss	0.68	0.002**	0.72	0.001**
Creatine vs energy loss	0.65	0.003**	0.66	0.003**
Succinic acid vs energy loss	0.15	0.295	0.22	0.221
Taurine vs energy loss	0.22	0.204	0.14	0.307

^aBiosignature: SUM-3 = creatine + succinic acid + taurine; SUM-2 = creatine + succinic acid
^bStatistical significance: *significant at p ≤ 0.05, **significant at p ≤ 0.01
^cPain: No pain = 0; Unbearable pain = 10
^dEnergy: Lots of energy = 0; No energy = 10

ISSN: 1471-2377