Table 1 Characteristics of Chinese PD patients with and without ICRDs
Mean ± SD | ||||
|---|---|---|---|---|
Characteristic | All(n = 142) | Without ICRDs(n = 98) | ICRDs Positive(n = 44) | P value |
Male,% | 51.4 | 55.1 | 43.2 | 0.208 |
Age at study,y | 68.39 ± 8.14 | 69.67 ± 8.16 | 65.55 ± 7.43 | 0.005 |
Age of PD onset,% | <0.001 | |||
≤55y | 24.6 | 15.3 | 45.5 | |
56-60y | 16.2 | 16.3 | 15.9 | |
>60y | 59.2 | 68.4 | 38.6 | |
PD duration,y | 6.00 ± 5.56 | 5.22 ± 5.23 | 7.76 ± 5.90 | 0.010 |
Current Smoking,% | 21.1 | 16.3 | 31.8 | 0.037 |
Current Alcoholism,% | 16.2 | 18.4 | 11.4 | 0.336 |
L-dopa medication,% | 68.3 | 64.3 | 77.3 | 0.172 |
DA medication,% | 49.3 | 40.8 | 68.2 | 0.003 |
Total LEDD,mg | 389.40 ± 373.72 | 329.82 ± 340.65 | 522.06 ± 412.46 | 0.006 |
L-dopa LEDD,% | 0.061 | |||
≤250 mg | 43.7 | 48.0 | 34.1 | |
250-500 mg | 32.4 | 33.7 | 29.5 | |
>500 mg | 23.9 | 18.4 | 36.4 | |
DA LEDD,% | <0.001 | |||
≤50 mg | 63.4 | 71.4 | 45.5 | |
51-100 mg | 25.4 | 24.5 | 27.3 | |
>100 mg | 11.3 | 4.1 | 27.3 | |
L-dopa treatment duration,y | 3.89 ± 5.25 | 3.42 ± 5.21 | 4.98 ± 5.23 | 0.042 |
DA treatment duration,y | 1.93 ± 3.00 | 1.44 ± 2.32 | 3.03 ± 3.93 | 0.020 |
H&Y stage | 2.25 ± 0.84 | 2.21 ± 0.77 | 2.32 ± 0.99 | 0.727 |
UPDRS Total | 33.23 ± 19.06 | 32.17 ± 19.32 | 35.59 ± 18.46 | 0.208 |
UPDRS I | 3.17 ± 1.77 | 3.13 ± 1.79 | 3.25 ± 1.77 | 0.710 |
UPDRS II | 9.61 ± 6.22 | 9.34 ± 5.97 | 10.23 ± 6.79 | 0.666 |
UPDRS III | 19.32 ± 12.42 | 18.93 ± 12.82 | 20.18 ± 11.56 | 0.390 |
UPDRS IV | 0.99 ± 2.27 | 0.57 ± 1.39 | 1.93 ± 3.36 | 0.020 |
UPDRS 32 + 33 | 0.29 ± 1.00 | 0.11 ± 0.66 | 0.68 ± 1.46 | 0.001 |
Freezing of gait | 4.10 ± 7.41 | 2.96 ± 6.40 | 6.64 ± 8.85 | 0.010 |
MMSE score, % | 0.049 | |||
10–20 | 12.0 | 8.2 | 20.5 | |
21–26 | 27.5 | 25.5 | 31.8 | |
≥27 | 60.6 | 66.3 | 47.7 | |
NMS score | 27.51 ± 22.07 | 27.29 ± 23.67 | 28.02 ± 18.24 | 0.318 |
HAMA score | 6.49 ± 5.30 | 5.83 ± 5.15 | 7.95 ± 5.40 | 0.020 |
HAMD score | 7.63 ± 7.50 | 7.53 ± 7.58 | 7.84 ± 7.39 | 0.657 |
RBDSQ-HK score | 18.15 ± 15.78 | 17.36 ± 16.20 | 19.93 ± 14.83 | 0.192 |
PDQ-39 score | 20.28 ± 18.28 | 19.95 ± 18.19 | 21.02 ± 18.66 | 0.752 |