Fig. 7

EAE animals present decreased contact area of the paw prints at the chronic disease. a Front paws print width. EAE (continuous line): Basal vs 25, 28, 36 and 42 dpi (p < 0.05), 19 dpi vs 12 and 42 dpi (p < 0.05) and 5 and 22 dpi vs 42 dpi. EAE-Ex (dashed line): Basal vs 12, 25–31 and 42 dpi (p < 0.05) and 5 dpi vs 12 and 42 dpi. ++ Represents p < 0.01 between EAE and EAE-Ex at Basal time point. b Hind paws print width. EAE (continuous line): Basal vs 19, 25 and 28 dpi (p < 0.05). EAE-Ex (dashed line): Basal vs 22–28 dpi (p < 0.05). c Front paws print length. EAE (continuous line): Basal vs 12, 25 and 42 dpi (p < 0.05). EAE-Ex (dashed line): Basal vs 12 and 42 dpi (p < 0.01). d Hind paws print length. No differences detected. e Front paws print area. EAE (continuous line): Basal vs 12 and 25–42 dpi (p < 0.05). EAE-Ex (dashed line): Basal vs 05–12 and 22–42 dpi. f Hind paws print area. EAE-Ex (dashed line): Basal vs 25–28 dpi (p < 0.05). + Represents p < 0.05 between EAE and EAE-Ex at Basal time point