Fig. 1

Microscopic images showing examples of cerebral amyloid angiopathy (CAA) from aged human brain. Panel (a) is a low magnification view of β-amyloid (Aβ) immunolabeling with the monoclonal antibody 6E10 obtained from the temporal neocortex. Meningeal amyloid labeling is present along the cortical surface, with labelled individual arterioles of varying sizes invading and inside the cortex. Punctuate immunoreactive profiles occur along the low portion of layer I. Panels (b) and (c) are enlarged views of the framed areas in (a). Panels (d-g) are high power views of 6E10 immunolabeling with Nissl counterstain. Note the presence of perivascular amyloid deposition (pointed by arrows and arrowheads) in addition to the labeling in the wall of affected vessels, which appear diffuse (arrowheads) or compact (arrows) like in morphological pattern. Both large (c) and small (d, f) vessels can exhibit heavy immunolabeling at the inner layer of the vascular wall (open arrows). *: vascular cavity. Scale bar = 1 mm in (a), equal to 200 μm for other panels. Images are adapted from original data of recent studies [25, 162]