Fig. 1

White matter topographies related to serum homocysteine levels. a Fractional anisotropy: red; (b) Mean diffusivity: green; (c) Radial diffusivity; (d) Axial diffusivity. The images are displayed on a standard brain render with the threshold of p < 0.05 (threshold-free cluster enhancement method for multiple comparisons). The underlying black represents the white matter skeleton. Adjustments were made for serum creatinine and glomerular filtration rate according to the Modification of Diet in Renal Disease formula, vitamin B12 and folate levels