Fig. 5

Interaction between cerebral autoregulation and renal function on outcome accordingly to modified Rankin scale (a), risk of hemorrhage (b) and on severity of white matter lesions assessed at 24-h head Computed Tomography, accordingly to vanSwieten scale [33]. Subgroups were created by splitting renal function into low (< 60 mL/min/1.73 m²) and high (≥60 mL/min/1.73 m²) estimated glomerular filtration rate (eGFR); cerebral autoregulation into low (Lo gain) and high (Hi gain) subgroups of LF gain in infarct (≤ 0.90 and > 0.90%²/mmHg²) and non-infarct hemisphere (≤ 1.10 and > 1.10%²/mmHg²). Notice that higher gain values represents worse levels of cerebral autoregulation. The interaction effect in outcome and white matter lesions was tested in multinomial logistic or ordinal regression models as appropriate