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Table 3 Association between estimated glomerular filtration rate and cerebral autoregulation parameters in acute stroke (< 6 h)

From: Chronic kidney disease and poor outcomes in ischemic stroke: is impaired cerebral autoregulation the missing link?

 

Multiple Linear Regression – Beta coefficients and estimated 95% confidence interval

 

Coherence (a.u.)

Gain (%2/ mmHg2)

Phase (degrees)

 

LF band

HF band

LF band

HF band

LF band

HF band

Ipsilateral (N = 37)

 

 eGFR, ml/min

– 0.01 (− 0.01, 0.01)

– 0.08 (−  0.23, 0,15)

*– 0.01 (− 0.01,–0.004)

*– 0.02 (− 0.18,–0.003)

0.10 (−  0.24, 0.43)

– 0.08 (−  0.26, 0.14)

 CCB Use

– 0.32 (−  10.6, 0.75)

– 0.12 (−  10.6, 0.75)

* 0.52 (0.22, 0.71)

* 0.35 (0.06, 1.12)

0.17 (−  0.09, 0.26)

0.17 (−  0.05, 0.12)

 Mean ABP, mmHg

0.01 (−  0.01, 0.01)

0.06 (−  0.27, 0.37)

– 0.39 (−  0.02, 0.001)

– 0.01 (−  0.03, 0.01)

0.28 (−  1.21, 0.60)

0.28 (−  1.21, 0.60)

 Heart Rate, bpm

– 0.11 (−  0.01, 0.00)

– 0.02 (−  0.43, 0.37)

– 0.30 (−  0.03, 0.03)

– 0.32 (−  0.01, 0.02)

0.13 (−  0.33, 1.26)

0.24 (−  1.23, 0.23)

 EtCO2, mmHg

– 0.13 (−  0.01, 0.01)

– 0.03 (−  0.78, 0.67)

– 0.34 (−  0.08, 0.05)

– 0.23 (−  0.10, 0.02)

0.31 (−  0.10, .34)

0.13 (−  0.13, 2.31)

Contralateral (N = 46)

 

 eGFR, ml/min

– 0.19 (−0.01, 0.01)

0.09 (− 0.13, 0.25)

*– 0.01 (− 0.01,–0.004)

*– 0.02 (− 0.02,–0.004)

0.06 (−  0.23, 0.35)

0.09 (−  0.13, 0.25)

 CCB Use

– 0.15 (−  34.5, 10.2)

– 0.32 (−  45.6, 7.5)

* 0.40 (0.16, 0.81)

0.25 (− 0.04, 0.76)

0.14 (−  0.06, 0.24)

0.17 (−  0.05, 0.12)

 Mean ABP, mmHg

– 0.20 (−  0.01, 0.001)

0.10 (−  0.22, 0.45)

*– 0.02 (− 0.03,–0.01)

*– 0.02 (− 0.03, − 0.01)

0.17 (−  0.26, 0.84)

0.21 (−  1.23, 1.01)

 Heart Rate, bpm

– 0.08 (−  0.01, 0.003)

– 0.02 (−  0.45, 0.38)

– 0.15 (−  0.02, 0.01)

– 0.32 (−  0.01, 0.13)

– 0.04 (−  0.58, 1.03)

– 0.10 (−  2.33, 0.12)

 EtCO2, mmHg

– 0.03 (−  0.01, 0.01)

– 0.17 (−  1.12, 0.28)

– 0.29 (−  0.04, 0.00)

– 0.24 (−  0.01, 0.12)

0.13 (0.14, 2.56)

– 0.25 (−  0.23, 3.12)

  1. Estimated glomerular filtration rate (eGFR), arterial blood pressure (MBP), end-tidal carbon dioxide (EtCO2), low (LF: 0.03–0.15 Hz) and high (HF: 0.15–0.5 Hz) frequency spectral bands, a.u., arbitrary units
  2. *P < 0.01 for multivariate linear regression analysis adjusting for age, gender and all significantly related variables in univariate analysis (Additional file 1: Table S4)
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