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Table 2 Comparison of clinical features of PD with constipation pre-motor signs and constipation post-motor signs

From: A survey of subjective constipation in Parkinson’s disease patients in shanghai and literature review

Item constipation pre-motor signs constipation post-motor signs Test value P value
Number of case N = 69 N = 76 / /
Male/Femaleb 33/36 47/29 χ2 = 2.873 >  0.05
Age (year)a 70.45 ± 8.41 68.66 ± 11.30 t = 1.062 0.290
BMIa 22.91 ± 3.17 22.49 ± 2.92 t = 0.704 0.483
Moderate exerciseb 15(21.74%) 18(23.68%) χ2 = 0.078 >  0.05
Moderate drinkingb 34(49.28%) 46(60.53%) χ2 = 1.851 >  0.05
Smokingb 7(10.14%) 6(7.89%) χ2 = 0.224 >  0.05
Age of motor onset (year)a 66.83 ± 9.28 61.20 ± 8.93 t = 3.640 0.000
Age of diagnosis PD (year)a 67.02 ± 8.94 62.88 ± 9.56 t = 2.353 0.020
Motor onset to diagnosis (year)a 1.01 ± 0.97 1.51 ± 1.71 t = −1.955 0.053
Phenotype of onsetb
 tremor-dominant 43(62.32%) 43(56.58%) χ2 = 3.322 >  0.05
 Bradykinetic-rigid dominant 22(31.88%) 32(42.11%)
 others 4(5.80%) 1(1.32%)
Duration of motor signs (year)a 3.74 ± 3.96 8.50 ± 4.66 t = −6.507 0.000
Duration of constipationa 10.33 ± 10.13 4.48 ± 3.57 t = 4.521 0.000
Dose of levodopa (mg/d)a 467.89 ± 321.25 671.06 ± 338.72 t = −3.488 0.001
LED (mg/d)a 576.40 ± 368.61 807.22 ± 428.69 t = −3.254 0.001
Daily levodopa/kg (mg/kg)a 6.86 ± 6.05 11.15 ± 6.74 t = −4.019 0.000
UPDRS scorea 37.85 ± 24.96 49.55 ± 25.33 t = −2.759 0.007
UPDRSIII scorea 22.85 ± 14.72 28.58 ± 15.69 t = −2.229 0.027
H-Yc 2.02 ± 0.78 2.54 ± 0.87 t = 3.714 0.000
NMSSa 46.68 ± 39.06 58.85 ± 44.82 t = −1.663 0.099
MMSEa 26.68 ± 3.26 26.09 ± 4.37 t = −0.858 0.393
PDSSa 113.11 ± 26.27 110.08 ± 26.17 t = −0.618 0.538
HAMAa 12.10 ± 9.45 11.69 ± 9.47 t = −0.243 0.809
HAMDa 14.87 ± 11.57 15.84 ± 11.26 t = 0.477 0.634
PDQ-39a 31.79 ± 26.66 39.67 ± 29.34 t = −1.593 0.114
Mild constipationb 30(43.48%) 48(63.16%) χ2 = 6.161 <  0.05
Severe constipationb 38(55.07%) 26(34.21%)
CSSa 14.35 ± 5.43 12.00 ± 5.66 t = 2.490 0.014
PAC-QOLa 71.80 ± 29.36 70.26 ± 25.20 t = 0.287 0.775
  1. Moderate exercise: For adult, daily total physical activity is equivalent to at least 6000 steps accumulatively. Moderate drinking: 1.5-2 L/day
  2. LED: Levodopa equivalent doses were calculated as 100 mg L-dopa = 10 mg bromocriptine = 50 mg piribedil = 1 mg prampexole [5]
  3. Statistial significance (p< 0.05) in italics
  4. astatistic with t-test
  5. bstatistic with χ2 test