Table 2 Comparison of clinical features of PD with constipation pre-motor signs and constipation post-motor signs

Number of case

N = 69

N = 76

/

/

Male/Female^b

33/36

47/29

χ² = 2.873

>  0.05

Age (year)^a

70.45 ± 8.41

68.66 ± 11.30

t = 1.062

0.290

BMI^a

22.91 ± 3.17

22.49 ± 2.92

t = 0.704

0.483

Moderate exercise^b

15(21.74%)

18(23.68%)

χ² = 0.078

>  0.05

Moderate drinking^b

34(49.28%)

46(60.53%)

χ² = 1.851

>  0.05

Smoking^b

7(10.14%)

6(7.89%)

χ² = 0.224

>  0.05

Age of motor onset (year)^a

66.83 ± 9.28

61.20 ± 8.93

t = 3.640

0.000

Age of diagnosis PD (year)^a

67.02 ± 8.94

62.88 ± 9.56

t = 2.353

0.020

Motor onset to diagnosis (year)^a

1.01 ± 0.97

1.51 ± 1.71

t = −1.955

0.053

 tremor-dominant

43(62.32%)

43(56.58%)

χ² = 3.322

>  0.05

 Bradykinetic-rigid dominant

22(31.88%)

32(42.11%)

 others

4(5.80%)

1(1.32%)

Duration of motor signs (year)^a

3.74 ± 3.96

8.50 ± 4.66

t = −6.507

0.000

Duration of constipation^a

10.33 ± 10.13

4.48 ± 3.57

t = 4.521

0.000

Dose of levodopa (mg/d)^a

467.89 ± 321.25

671.06 ± 338.72

t = −3.488

0.001

LED (mg/d)^a

576.40 ± 368.61

807.22 ± 428.69

t = −3.254

0.001

Daily levodopa/kg (mg/kg)^a

6.86 ± 6.05

11.15 ± 6.74

t = −4.019

0.000

UPDRS score^a

37.85 ± 24.96

49.55 ± 25.33

t = −2.759

0.007

UPDRSIII score^a

22.85 ± 14.72

28.58 ± 15.69

t = −2.229

0.027

H-Y^c

2.02 ± 0.78

2.54 ± 0.87

t = 3.714

0.000

NMSS^a

46.68 ± 39.06

58.85 ± 44.82

t = −1.663

0.099

MMSE^a

26.68 ± 3.26

26.09 ± 4.37

t = −0.858

0.393

PDSS^a

113.11 ± 26.27

110.08 ± 26.17

t = −0.618

0.538

HAMA^a

12.10 ± 9.45

11.69 ± 9.47

t = −0.243

0.809

HAMD^a

14.87 ± 11.57

15.84 ± 11.26

t = 0.477

0.634

PDQ-39^a

31.79 ± 26.66

39.67 ± 29.34

t = −1.593

0.114

Mild constipation^b

30(43.48%)

48(63.16%)

χ2 = 6.161

<  0.05

Severe constipation^b

38(55.07%)

26(34.21%)

CSS^a

14.35 ± 5.43

12.00 ± 5.66

t = 2.490

0.014

PAC-QOL^a

71.80 ± 29.36

70.26 ± 25.20

t = 0.287

0.775