Table 3 Review and comparison with previous studies
Review of prevalence of constipation in PD according ROME III criteria | ||||||||
|---|---|---|---|---|---|---|---|---|
Study | Study population | Sample size (PD patients/Controls) | N of PD patients with constipation | Prevalence | Pooled prevalence | |||
Barichella et al. (2013) [15] | Italy | 208/0 | 124 | 59.6% | 50.88% | |||
Cassani et al. (2015) [16] | 102/50 | 58 | 57% | |||||
Barichella et al. (2016) [17] | 600/600 | 281 | 46.83% | |||||
Kaye J et al. (2006) [18] | UK | 156/148 | 92 | 59% | – | |||
The present study | China | 268/0 | 145 | 54.10% | – | |||
Review of prevalence and timespans of constipation before onset of motor symptoms | ||||||||
Study | Study population | Sample size (PD/Control) | Special inclusion criteria for PD | Criteria for constipation | Constipation prevalence at the time of evaluation | Prevalence of pre-motor constipation (% of PD subjects) | Timespans before onset of motor signs | |
Years (mean ± SD) | proportion | |||||||
Pont-Sunyer et al. (2015) [19] | Spain and Austria | 109/107 | untreated PD patients | Specific questionnaire | 38.5% | 78% | – | < 2 years 21% 2–10 years 15% > 10 years 63% |
Cersosimo et al. (2013) [20] | Argentina | 129/120 | no | Less than three bowel movements per week | 53.6% | 87% | 4 ± 4.6 | – |
Rodriguez-Violante et al. (2016) [21] | Mexico | 500/0 | no | NMSS | – | 32.8% | 9.25 ± 17.89 | – |
Schrag et al. (2015) [22] | UK | 8166/46755 | no | Database or use of laxatives | – | 28.19% | – | < 2 years 32% 2–5 years 25% 5–10 years 20% |
The present study | China | 268/0 | no | ROME III | 54.10% | 47.59% | 6.62 ± 9.32 | < 2 years 34.78% 2–10 years 46.38% > 10 years 18.84% |