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Table 3 Review and comparison with previous studies

From: A survey of subjective constipation in Parkinson’s disease patients in shanghai and literature review

Review of prevalence of constipation in PD according ROME III criteria
Study Study population Sample size (PD patients/Controls) N of PD patients with constipation Prevalence Pooled prevalence
Barichella et al. (2013) [15] Italy 208/0 124 59.6% 50.88%
Cassani et al. (2015) [16] 102/50 58 57%
Barichella et al. (2016) [17] 600/600 281 46.83%
Kaye J et al. (2006) [18] UK 156/148 92 59%
The present study China 268/0 145 54.10%
Review of prevalence and timespans of constipation before onset of motor symptoms
Study Study population Sample size (PD/Control) Special inclusion criteria for PD Criteria for constipation Constipation prevalence at the time of evaluation Prevalence of pre-motor constipation (% of PD subjects) Timespans before onset of motor signs
Years (mean ± SD) proportion
Pont-Sunyer et al. (2015) [19] Spain and Austria 109/107 untreated PD patients Specific questionnaire 38.5% 78% <  2 years 21% 2–10 years 15% >  10 years 63%
Cersosimo et al. (2013) [20] Argentina 129/120 no Less than three bowel movements per week 53.6% 87% 4 ± 4.6
Rodriguez-Violante et al. (2016) [21] Mexico 500/0 no NMSS 32.8% 9.25 ± 17.89
Schrag et al. (2015) [22] UK 8166/46755 no Database or use of laxatives 28.19% <  2 years 32% 2–5 years 25% 5–10 years 20%
The present study China 268/0 no ROME III 54.10% 47.59% 6.62 ± 9.32 <  2 years 34.78% 2–10 years 46.38% >  10 years 18.84%