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Table 3 Effect of dapagliflozin on Racine’s scores and TFMJ for PTZ–induced seizures in rats

From: Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy

Arm

Intervention

Racine’s

TFMJ (s)

p–value

B1

NS (control arm)

0 ± 0.0

Not reached

–

B2

NS, PTZ 70 mg/kg

5.5 ± 0.2

68.3 ± 3.4 s

–

B3

NS, PTZ 70 mg/kg, DGF 75 mg/kg

2.33 ± 0.5

196.7 ± 23.0 s

p < 0.0001

B4

NS, PTZ 70 mg/kg, DGF 150 mg/kg

2.1 ± 0.5

268.3 ± 23.1 s

p < 0.0001

  1. When compared to the B2 no dapagliflozin (DGF) arm, intraperitoneal (IP) dapagliflozin at 75 mg/kg and 150 mg/kg resulted in significantly reduced mean Racine’s scores by over 3 points, and improved mean time to first myoclonic jerk (TFMJ)—as measured in seconds—by a factor of over 2.5×, with p–value of < 0.0001, in rats treated with 70 mg/kg of IP pentylenetetrazol (PTZ). The ± range represents the standard deviation (SD) from the mean
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BMC Neurology

ISSN: 1471-2377

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