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Table 3 Effect of dapagliflozin on Racine’s scores and TFMJ for PTZ–induced seizures in rats

From: Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy

Arm Intervention Racine’s TFMJ (s) p–value
B1 NS (control arm) 0 ± 0.0 Not reached
B2 NS, PTZ 70 mg/kg 5.5 ± 0.2 68.3 ± 3.4 s
B3 NS, PTZ 70 mg/kg, DGF 75 mg/kg 2.33 ± 0.5 196.7 ± 23.0 s p < 0.0001
B4 NS, PTZ 70 mg/kg, DGF 150 mg/kg 2.1 ± 0.5 268.3 ± 23.1 s p < 0.0001
  1. When compared to the B2 no dapagliflozin (DGF) arm, intraperitoneal (IP) dapagliflozin at 75 mg/kg and 150 mg/kg resulted in significantly reduced mean Racine’s scores by over 3 points, and improved mean time to first myoclonic jerk (TFMJ)—as measured in seconds—by a factor of over 2.5×, with p–value of < 0.0001, in rats treated with 70 mg/kg of IP pentylenetetrazol (PTZ). The ± range represents the standard deviation (SD) from the mean