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Table 3 The AUC and the sensitivity / specificity at the optimal cut-off point of the PainDETECT under the condition of equal costs of misclassification to classify NePC by the classification and the Grading System of the physicians

From: Avoiding Catch-22: validating the PainDETECT in a population of patients with chronic pain

PainDETECT versus classification by:

NePC:

AUC %

(95%CI)

Cut -off

Sens %

(95% CI)

Spec %

(95% CI)

Absent (n)

Present (n)

Assessment A

83

208

69.8

(0.63–0.77)

9

86.0

(0.81–0.90)

45.8

(0.36–0.57)

Assessment B

96

195

67.2

(0.61–0.74)

11

75.4

(0.69–0.81)

52.1

(0.42–0.62)

Assessment A = Assessment B

58

170

72.1

(0.65–0.80)

11

80.0

(0.73–0.85)

55.2

(0.43–0.67)

LBLP

28

75

75.4

(0.65–0.86)

11

84.0

(0.74–0.91)

64.3

(0.46–0.79)

NSA pain

18

23

62.9

(0.46–0.80)

9

82.6

(0.63–0.93)

44.4

(0.25–0.66)

Suspected PND pain

12

72

75.5

(0.63–0.88)

15

55.6

(0.44–0.67)

91.7

(0.65–0.99)

Grading A

114

172

58.9

(0.52–0.66)

11

73.3

(0.66–0.79)

43.9

(0.35–0.53)

Grading B

130

158

58.6

(0.52–0.65)

14

57.6

(0.50–0.65)

59.2

(0.51–0.67)

Grading A = Grading B

93

139

61.3

(0.54–0.69)

11

74.1

(0.66–0.81)

46.2

(0.37–0.56)

LBLP

60

48

63.1

(0.52–0.74)

12

70.8

(0.57–0.82)

55.0

(0.43–0.67)

NSA pain

24

13

48.9

(0.28–0.69)

18

30.8

(0.13–0.58)

87.5

(0.69–0.96)

Suspected PND pain

9

78

66.0

(0.45–0.87)

13

64.1

(0.53–0.74)

77.8

(0.45–0.94)

Assessment A = Grading A

63

155

69.1

(0.61–0.77)

11

76.1

(0.69–0.82)

55.6

(0.43–0.67)

Assessment B = Grading B

77

139

67.1

(0.60–0.74)

11

76.3

(0.69–0.83)

52.0

(0.41–0.63)

Assessment A = Grading A = Assessment B = Grading B

43

118

67.9

(0.59–0.77)

11

78.0

(0.70–0.85)

53.0

(0.39–0.68)

  1. Classification of NePC is based on (both) physicians’ assessment of the patients and / or on (both) the NeuPSIG Grading Systems
  2. NEPC: Neuropathic pain component existing; Absent NePC: Neuropathic pain component not existing; AUC: Area under curve; 95%CI: 95% confidence interval; Cut-off: Cut-off value; Sens.: Sensitivity; Spec.: Specificity; LBLP: Patients with low back and leg pain; NSA pain: Patients with neck-shoulder-arm pain; suspected PND pain: Patients with pain due to a suspected peripheral nerve damage