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Table 3 Course of symptom severity, restless legs syndrome, and pain throughout the BETASLEEP study

From: Sleep quality, daytime sleepiness, fatigue, and quality of life in patients with multiple sclerosis treated with interferon beta-1b: results from a prospective observational cohort study

Characteristic Baseline visit 6-month visit 12-month visit 18-month visit 24-month visit
All Patients Good sleepers (PSQI< 5) Poor sleepers (PSQI≥5) All Patients Good sleepers (PSQI< 5) Poor sleepers (PSQI≥5) All Patients Good sleepers (PSQI< 5) Poor sleepers (PSQI≥5) All Patients Good sleepers (PSQI< 5) Poor sleepers (PSQI≥5) All Patients Good sleepers (PSQI< 5) Poor sleepers (PSQI≥5)
EDSS N = 128 N = 35 N = 71 N = 90 N = 26 N = 50 N = 75 N = 25 N = 40 N = 50 N = 16 N = 27 N = 49 N = 17 N = 25
 Median (range) 2.0 (0.0–5.0) 2.0 (0.0–5.0) 2.0 (0.0–5.0) 2.0 (0.0–6.5) 2.0 (0.0–4.0) 2.0 (0.0–6.5) 2.0 (0.0–6.5) 1.5 (0.0–4.5) 2.0 (0.0–6.5) 2.0 (0.0–6.5) 1.5 (0.0–4.5) 2.0 (0.0–6.5) 2.0 (0.0–5.0) 1.5 (0.0–5.0) 2.0 (0.0–5.0)
MSFC N = 93 N = 26 N = 55     N = 54 N = 18 N = 31     N = 31 N = 8 N = 17
 Median (range) 0.11 (− 3.46–1.49) 0.21 (− 1.01–0.69) 0.08 (− 3.46–1.49)     0.20 (− 1.13–0.87) 0.26 (− 0.76–0.87) 0.22 (− 1.13–0.80)     0.17 (− 1.52–0.99) 0.20 (− 0.46–0.73) 0.17 (− 1.52–0.99)
RLS, evaluable patients (N) N = 128 N = 35 N = 67 N = 109 N = 33 N = 59 N = 96 N = 31 N = 50 N = 65 N = 20 N = 34 N = 61 N = 20 N = 31
 n (%) 5 (3.9) 0 4 (6.0) 3 (2.8) 0 2 (3.4) 4 (4.2) 0 2 (4.0) 1 (1.5) 0 1 (2.9) 2 (3.3) 0 2 (6.5)
HSAL N = 7 N = 1 N = 5 N = 6 N = 1 N = 3 N = 5 N = 1 N = 2 N = 4 N = 1 N = 2 N = 3 N = 0 N = 2
 Median (range) 111.0 (18–193) 18.0 (18–18) 111.0 (38–193) 42.5 (0–151) 0.0 (0–0) 50.0 (6–133) 48.0 (0–89) 0.0 (0–0) 62.5 (48–77) 61.5 (0–109) 0.0 (0–0) 61.5 (30–93) 124.0 (26–137) 75.0 (26–124)
  1. Numbers of good sleepers (PSQI< 5) and poor sleepers (PSQI≥5) do not add up to number of all patients due to missing PSQI baseline values
  2. PSQI Pittsburgh Sleep Quality Index, EDSS Expanded Disability Status Scale, RLS restless legs syndrome, MSFC Multiple Sclerosis Functional Composite, SD standard deviation, HSAL Hamburg Pain Adjective List